Results 121 to 130 of about 506,486 (268)

Knowledge of Predatory Practices within the Substance Use Disorder Treatment Industry: Development of a Measurement Instrument. [PDF]

Int J Environ Res Public Health, 2022
Farmer AY, Wei Y, Powell KG, Treitler P, Killawi A, Lardier D, Peterson NA, Borys S, Hallcom DK.   +8 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Power management for triboelectric and electrostatic generators enabling continuous and stable power delivery

Nature Communications
Power management is essential for effectively utilizing energy harvested from triboelectric and electrostatic generators. However, current strategies suffer from control and conversion challenges such as inefficient switch designs and load-dependent ...
Zeyuan Cao, Junchi Teng, Yongjia Zhao, Xingqi Guo, Jiani Xu, Chao Ren, Xiongying Ye   +6 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Electrostatic generator enhancements for powering IoT nodes via efficient energy management

Microsystems & Nanoengineering
Electrostatic generators show great potential for powering widely distributed electronic devices in Internet of Things (IoT) applications. However, a critical issue limiting such generators is their high impedance mismatch when coupled to electronics ...
Zibo Wu, Zeyuan Cao, Junchi Teng, Rong Ding, Jiani Xu, Xiongying Ye   +5 more
doaj   +1 more source

Standardization of Quality of Diagnoses, Interventions, and Outcomes (Q-DIO) Measurement Instrument for Use in Slovenia. [PDF]

Zdr Varst, 2022
Gruden MK, Müller-Staub M, Pajnkihar M, Štiglic G.   +3 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Metasurface array for single-shot spectroscopic ellipsometry

Light: Science & Applications
Spectroscopic ellipsometry is a potent method that is widely adopted for the measurement of thin film thickness and refractive index. Most conventional ellipsometers utilize mechanically rotating polarizers and grating-based spectrometers for ...
Shun Wen, Xinyuan Xue, Shuai Wang, Yibo Ni, Liqun Sun, Yuanmu Yang   +5 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

A Novel Tongue Pressure Measurement Instrument with Wireless Mobile Application Control Function and Disposable Positioning Mouthpiece. [PDF]

Diagnostics (Basel), 2021
Liu HY, Chen CH, Kuo CH, Feng MC, Chen JH, Wang HW, Chen KC, Lin CL.   +7 more
europepmc   +1 more source