Results 71 to 80 of about 506,486 (268)

Experimental Study and Parameter Optimization of a Magnetic Coupled Piezoelectric Energy Harvester

open access: yesApplied Sciences, 2018
Piezoelectric energy harvesting is a promising way to develop self-sufficient systems. Structural design and parameter optimization are key issues to improve the performance in applications.
Xiaobo Rui   +4 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nitride–Silver Hybrid PCF-SPR Biosensor: A High-Sensitivity Platform for Synchronous Monitoring of Low-Concentration Analytes and Temperature

open access: yesSensors
This study proposes a dual-parameter photonic crystal fiber-based surface plasmon resonance (SPR) sensor for simultaneous refractive index and temperature detection.
Chenyu Liang   +4 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Smart Sensing Strip Using Monolithically Integrated Flexible Flow Sensor for Noninvasively Monitoring Respiratory Flow

open access: yesSensors, 2015
This paper presents a smart sensing strip for noninvasively monitoring respiratory flow in real time. The monitoring system comprises a monolithically-integrated flexible hot-film flow sensor adhered on a molded flexible silicone case, where a ...
Peng Jiang, Shuai Zhao, Rong Zhu
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Centralized exhaust system simulation and parameter optimization

open access: yesScientific Reports
With the increase in high-rise buildings in cities, public flue exhaust systems have a direct impact on residential air quality and the living environment.
Mingming Lu   +9 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Coagulation Characteristics of Nano-agglomerates in Free Molecular States under Different Electric Field Intensities

open access: yesAerosol and Air Quality Research
The coagulation behavior of nanoparticles in microfluidic chip channels is complex and affected by various external factors, including electric fields, sound fields, and wakes.
Ting Luo   +9 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

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