Results 161 to 170 of about 5,839,450 (292)

Accurate Concentration Measurement Model of Multicomponent Mixed Gases during a Mine Disaster Period. [PDF]

ACS Omega, 2022
Li F, Wang C, Zhang Y, He X, Zhang C, Sha F.   +5 more
europepmc   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Determination of the Isotopic Composition of Indium by MC-ICP-MS Using an Improved Measurement Model for the Gravimetric Isotope Mixture Method. [PDF]

Anal Chem
Meija J, Nadeau K, Methven B, Yang L.
europepmc   +1 more source

Validation of the Measurement Model of the Grief Support Healthcare Scale Among the Intensive Care Unit Nurses in Malaysia. [PDF]

Florence Nightingale J Nurs, 2022
Jit Singh GK, Low WY, Abdullah KL.
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Measurement model for community enterprise management strategies. [PDF]

Heliyon
Jarusen J, Cheunkamon E.
europepmc   +1 more source

Development and validation of assessments of adolescent health literacy: a Rasch measurement model approach. [PDF]

BMC Public Health, 2022
Fleary SA, Freund KM, Nigg CR.
europepmc   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Rasch Measurement Model Supports the Unidimensionality and Internal Structure of the Arabic Oswestry Disability Index. [PDF]

J Clin Med
Alnahdi AH, Alsubiheen AM, Aldaihan MM.
europepmc   +1 more source

Development and Validation of the Adolescent Media Health Literacy Scales: Rasch Measurement Model Approach. [PDF]

JMIR Pediatr Parent, 2022
Fleary SA.
europepmc   +1 more source