Results 181 to 190 of about 2,250,709 (315)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

The analysis of Cox regression model when covariates are subject to heteroscedastic measurement errors

open access: yes, 2012
碩士在本文中,我們探討Cox比例風險模型中自變數有異質性(heteroscedastic)測量誤差時的迴歸參數估計方法;若量測次數與存活時間相關時,那麼平均量測值的變異數會與存活時間有關,就會造成異質性測量誤差的問題。本文使用小測量誤差的估計方法,它不需在測量誤差上有分配的假設,直接以泰勒展開式來近似含有測量誤差的分數函數;除此之外,再與其它文獻所提過的估計方法一起做比較,這其中還包含新的誤差增量估計方法。最後我們利用電腦模擬在許多不同情況下各種估計方法的表現,並對結果加以討論。We consider ...
黃揚閔; Huang, Yang-Min
core  

Measuring modelling

open access: yes, 2020
ISSN:2624 ...
van Vliet, Oscar; id_orcid0000-0002-3964-428X   +1 more
openaire   +1 more source

Service Value and Repurchase Intention in the Egyptian Fast-Food Restaurants: Toward a New Measurement Model. [PDF]

open access: yesInt J Environ Res Public Health, 2022
Doeim AR   +5 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

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