Results 161 to 170 of about 2,250,709 (315)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

A measurement model of older adults’ emotional experience in the interior environments of community-based adult daycare centers in China

Environmental Research Communications
Emotional experience has become increasingly important in community-based adult daycare centers (CADCs) for older adults because inadequately designed interior environments can intensify stress, discomfort, and social withdrawal, thereby undermining ...
Lintong Li, Suhua Wang, Noranita Mansor, Athira Azmi, Chun Ye, Jialing Xiang   +5 more
doaj   +1 more source

Supervised latent Dirichlet allocation with covariates: A Bayesian structural and measurement model of text and covariates. [PDF]

Psychol Methods, 2023
Wilcox KT, Jacobucci R, Zhang Z, Ammerman BA.   +3 more
europepmc   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

The raters' differences in Arabic writing rubrics through the Many-Facet Rasch measurement model. [PDF]

Front Psychol, 2022
Baharudin H, Maskor ZM, Matore MEEM.
europepmc   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

PC-Base Impedance Measurement System For Piezoelectric Transducers and Its Implementation on Elements Values Extraction of Lump Circuit Model

, 2012
[[abstract]]Tonpiltz transducer are the popular elements for sonar array. The transducer of the simplify electrical equivalent circuit is discussed, and a method for determining element values at or near resonance is described.
陳永欽;Chen, Yeong-Chin
core  

CRISPR-Cas13d: RNA’s own Jedi Master in the fight against viral darkness

Molecular Therapy: Nucleic Acids
Zacharias Kontarakis, Omer Revah, Andrea Rossi   +2 more
doaj   +1 more source

Application of the Rasch measurement model in rehabilitation research and practice: early developments, current practice, and future challenges. [PDF]

Front Rehabil Sci, 2023
Tennant A, Küçükdeveci AA.
europepmc   +1 more source