Results 201 to 210 of about 5,839,450 (292)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Estimation of Weight and Body Measurement Model for Pigs Based on Back Point Cloud Data. [PDF]

Animals (Basel)
Liu Y, Zhou J, Bian Y, Wang T, Xue H, Liu L.   +5 more
europepmc   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Power analyses for measurement model misspecification and response shift detection with structural equation modeling. [PDF]

Qual Life Res
Verdam MGE.
europepmc   +1 more source

A Country Pandemic Risk Exposure Measurement Model. [PDF]

Risk Manag Healthc Policy, 2020
Grima S, Kizilkaya M, Rupeika-Apoga R, Romānova I, Dalli Gonzi R, Jakovljevic M.   +5 more
europepmc   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Estimation of Respiratory States Based on a Measurement Model of Airflow Characteristics in Powered Air-Purifying Respirators Using Differential Pressure and Pulse Width Modulation Control Signals-In the Development of a Public-Oriented Powered Air-Purifying Respirator as an Alternative to Lockdown Measures. [PDF]

Sensors (Basel)
Fujii Y, Takita A, Hashimoto S, Amagai K.   +3 more
europepmc   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

The reflective measurement model of adherence to non-pharmaceutical interventions (NPIs) in accordance with normalization process theory (NPT) in coherent and convenient social subgroups: PLS-SEM analysis. [PDF]

Eur J Public Health
Pletikosa Pavic M, Pranic SM, Mastelic T, Kljucevic Z, Gotovac M, Savicevic AJ, Kozina T, Kozina S.   +7 more
europepmc   +1 more source

A Measurement Model of Mutual Influence for Information Dissemination. [PDF]

Entropy (Basel), 2020
Zhang L, Quan Y, Zhou B, Jia Y, Gao L.
europepmc   +1 more source