Results 101 to 110 of about 4,485,248 (291)

Validating Dart Model

open access: yesInternational Journal of Management and Economics, 2014
The primary objective of the study was to quantitatively test the DART model, which despite being one of the most popular representations of co-creation concept was so far studied almost solely with qualitative methods.
Mazur Jolanta, Zaborek Piotr
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Does Measurement Error Explain a Paradox About Household Size and Food Demand? Evidence from Variation in Household Survey Methods [PDF]

open access: yes
Several recent papers report a puzzling pattern of food demand falling as household size rises at constant per capita expenditure, especially in poorer countries. This pattern is contrary to a widely used model of scale economics.
Gibson, John
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

A Review and Content Validation of 10 Measurement Scales for Parental Mediation of Children’s Internet Use

open access: yesInternational Journal of Communication, 2021
For the last decade, research has shown inconsistent findings about validity of parental mediation scales for children’s Internet use. This inconsistency has manifested itself in at least 10 parental mediation models, which are also inconsistent in ...
Seffetullah Kuldas   +3 more
doaj  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

La présence socio-affective en e-Formation : le modèle théorique de référence, l’élaboration et la validation de l’échelle de mesure EMPSA e-Formation

open access: yesMesure et Évaluation en Éducation
L’article décrit le processus d’élaboration et de validation de l’Échelle de Mesure de la Présence Socio-Affective en Formation (EMSPA e-Formation).
Annie Jézégou   +2 more
doaj   +1 more source

Instrumentalising the Internal Control of Material Resources in an Industrial Enterprise to Provide Information Base for Management Decisions

open access: yesУчёт. Анализ. Аудит
The article deals with the problems of instrumentalisation of the function of on-farm control of consumption of material resources in the production activities of industrial enterprises.
I. E. Mizikovskу
doaj   +1 more source

Aggregate returns to scale: why measurement is imprecise [PDF]

open access: yes
The extent to which there are aggregate returns to scale at the level of aggregate production has important implications both for the types of shocks generating business cycles and for optimal policy.
Harold L. Cole, Lee E. Ohanian
core   +1 more source

Home - About - Disclaimer - Privacy