Results 101 to 110 of about 1,560,969 (307)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Assessment of Student Performance for Laboratory Application Course Examination Using Rasch Measurement Model

Rasch Measurement Model creation in social science education has quickly spread to other educational domains, such as technical and engineering sciences. This research attempts to move testing and assessment in Laboratory Application in Science Education
Ocal, Zekiye Merve, Yüzüak, Ahmet Volkan   +1 more
core   +1 more source

Measuring internship quality in education: A Systematic review and comparative synthesis of internship scales

Jurnal Pendidikan Vokasi
Internship programs play a strategic role in bridging academic learning and workplace practice; however, the quality of these programs is often assessed using diverse and fragmented instruments.
Olievia Prabandini Mulyana, Nur Hidayah, Nur Eva, Ninik Setiyowati, Amin Al Haadie Shafie   +4 more
doaj   +1 more source

Validating Dart Model

International Journal of Management and Economics, 2014
The primary objective of the study was to quantitatively test the DART model, which despite being one of the most popular representations of co-creation concept was so far studied almost solely with qualitative methods.
Mazur Jolanta, Zaborek Piotr
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

La présence socio-affective en e-Formation : le modèle théorique de référence, l’élaboration et la validation de l’échelle de mesure EMPSA e-Formation

Mesure et Évaluation en Éducation
L’article décrit le processus d’élaboration et de validation de l’Échelle de Mesure de la Présence Socio-Affective en Formation (EMSPA e-Formation).
Annie Jézégou, Yihuan Zhao, Moïse Déro   +2 more
doaj   +1 more source

Study on thermal-hydraulic response characteristics of internal compartments in the containment building under LOCA conditions

International Journal of Advanced Nuclear Reactor Design and Technology
Investigating the thermal-hydraulic response characteristics of internal compartments within the containment structure during LOCA accidents holds significant scientific, engineering, and safety value for elucidating accident evolution mechanisms ...
Shilei Dun, Tao Zhou, Haoyv Li, Lanyv Zhou, Yao Yao, Changhong Peng, Shuyv He   +6 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Measurement and Characterisation of Micro/nano-scale Structured Surfaces

Micro/nano-scale structured surfaces play a critical role in precision engineering. For Microelectromechanical Systems (MEMS), they are key factors to ensure the system's functional performance. However, the measurement and characterisation of micro/nano-
Zhu, Hao
core