Results 121 to 130 of about 1,084,034 (311)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Cartesian approach to large scale co-ordinate measurement: InPlanT

, 2014
A novel paradigm of coordinate measurement is presented, named InPlanT. The target application is the industrial measurement of large workpieces in harsh conditions, e.g. in aerospace industry.
PISANI, MARCO, BALSAMO, ALESSANDRO, Francese C.   +2 more
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Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Review of the application of high temperature superconductors in coated conductor development and the measurement of their properties

, 2005
Since the 1960s, Nb-Ti, exhibiting a superconducting transition temperature Tc of 9K, and Nb3Sn, with a Tc of 18K have been the materials of choice for superconducting applications.
Bruneel, ElsWE068010009432800000-0002-6527-004XF4C6AE2E-F0ED-11E1-A9DE-61C894A0A6B4, Van Driessche, IsabelWE06WE51WE628010007010830000-0001-5253-3325F4614F2A-F0ED-11E1-A9DE-61C894A0A6B4, Penneman, Greet, Van Driessche, Isabel, Hoste, Serge, Hoste, SergeUGent801000316824972603757559F3AECC4C-F0ED-11E1-A9DE-61C894A0A6B4, Bruneel, Els, Schoofs, Bart8010017085706F8A37BC-B25E-11E6-B104-2D2FD0AF0289, Schoofs, Bart, Penneman, Greet80100150123472FD2896-B25E-11E6-B104-2D2FD0AF0289   +9 more
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Customized measuring station for Peltier modules

Heliyon
Peltier modules control temperatures in niche products such as wine coolers and camping fridges or are used to precisely temper processes as for example the duplication of DNA sections.
Roland Binninger, Sabrina Unmüßig, Marc Vergez, Markus Bartel, Olaf Schäfer-Welsen   +4 more
doaj   +1 more source

Quality assessment of integrated water vapour measurements at the St. Petersburg site, Russia: FTIR vs. MW and GPS techniques

, 2020
The cross-comparison of different techniques for atmospheric integrated water vapour (IWV) measurements is the essential part of their quality assessment protocol.
Blumenstock T., Virolainen Y., Imhasin H., Makarova M., Ionov D., Kalinnikov V., Poberovsky A., Polyakov A., Timofeyev Y., Hase F., Barthlott S., Kostsov V., Zaitsev N., Schneider M.   +13 more
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Proceedings of Seventh International Symposium "Monitoring of Mediterranean Coastal Areas. Problems and Measurement Techniques" [PDF]

, 2018
The Seventh International Symposium Monitoring of Mediterranean Coastal Areas. Problems and Measurement Techniques (Livorno, Italy June 19-20-21, 2018) was organized by the CNR-IBIMET in collaboration with the City of Livorno, the LEM Foundation, the FCS

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