Results 131 to 140 of about 1,084,034 (311)

Aerosol measurement methods to quantify spore emissions from fungi and cryptogamic covers in the Amazon

, 2019
Bioaerosols are considered to play a relevant role in atmospheric processes, but their sources, properties, and spatiotemporal distribution in the atmosphere are not yet well characterized. In the Amazon Basin, primary biological aerosol particles (PBAPs)
Brill, Sebastian, Pöhlker, Christopher, Brill, S., Pöschl, U., Kesselmeier, Jürgen, de Oliveira, Leonardo R., Araüjo, Alessandro Carioca de, de Oliveira Sá, Marta, de Araújo, Alessandro C., de Sá, M., Löbs, Nina, Weber, Bettina, Oliveira Sá, Marta de, Walter, D., Godoi, R., de Oliveira, L., Walter, David, Andreae, Meinrat O., Pöschl, Ulrich, Artaxo, P., Piepenbring, Meike, Andreae, M., Barbosa, Cybelli G. G., Wolff, S., Pöhlker, C., Piepenbring, M., Weber, B., Sa, M., Barbosa, Cybelli G.G., Artaxo, Paulo, Kesselmeier, J., Godoi, Ricardo H. M., Löbs, N., Oliveira, Leonardo Ramos de, Godoi, Ricardo Henrique Moreton, Ditas, F., Wolff, Stefan, Sá, Marta de Oliveira, Oliveira, Leonardo R. de, de Araújo, A., Araújo, Alessandro C. de, Ditas, Florian, Barbosa, C.   +42 more
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Optical Measurement System for Monitoring Railway Infrastructure—A Review

Applied Sciences
Rail infrastructure plays an important role in fulfilling the demand for freight and passenger transportation. Increases in traffic volume, heavier axles and vehicles, higher speeds, and increasing climate extremes all contribute to the constant strain ...
Kira Zschiesche, Alexander Reiterer
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

The Binding of the SARS-CoV-2 Spike Protein to Platelet Factor 4: A Proposed Mechanism for the Generation of Pathogenic Antibodies

Biomolecules
Pathogenic platelet factor 4 (PF4) antibodies contributed to the abnormal coagulation profiles in COVID-19 and vaccinated patients. However, the mechanism of what triggers the body to produce these antibodies has not yet been clarified.
Thi-Huong Nguyen, Li-Yu Chen, Nida Zaman Khan, Annerose Lindenbauer, Van-Chien Bui, Peter F. Zipfel, Doris Heinrich   +6 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Measurement Techniques for the Optical Quality Assessment of Parabolic Trough Collector Fields in Commercial Solar Power Plants

, 2007
The optical quality of the collector field of concentrating solar power plants is a fundamental factor for their profitability. High optical quality can be achieved and guaranteed when the manufacturing process is continuously monitored and adjusted in ...
Pottler, Klaus, Lüpfert, Eckhard, Eckhard Lüpfert, Marc Röger, Ulmer, Steffen, Steffen Ulmer, Klaus Pottler, Röger, Marc   +7 more
core  

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

A comparison of inequality measurement techniques [PDF]

There are numerous statistical techniques designed for the measurement of inequality. Each individual index has a unique set of properties which can make the choice of an appropriate measure difficult.
Nicholas Rohde
core