Results 81 to 90 of about 1,746,399 (312)

Economic impact of training and education in basic skills: summary of evidence (BIS research paper no.6) [PDF]

open access: yes, 2009
This paper summarises recent quantitative evidence on the economic returns to having or improving literacy and numeracy skills. The summary includes evidence on earnings and employment, and distinguishes between returns to having basic skills whenever ...

core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

Mobile device use in the primary school classroom and impact on pupil literacy and numeracy attainment: A systematic review

open access: yesCampbell Systematic Reviews
Background Investment in mobile devices to support primary or elementary education is increasing and must be informed by robust evidence to demonstrate impact.
Claire Dorris   +3 more
doaj   +1 more source

National E-Systems for Combating VAT Evasion and Intra-EU Trade. Hungary’s ‘EAKER’ and Romania’s ‘RO e-Transport’

open access: yesEuropean Papers
(Series Information) European Papers - A Journal on Law and Integration, 2025 10(1), 55-96 | Article | (Table of Contents) 1. Introduction. – 2. A quick look at border and other types of checks. – 3. An overview of the two systems. – 3.1. Hungary’s EKAER.
Szilárd Gáspár-Szilágyi   +1 more
doaj   +1 more source

Toward a protocol for quantifying the greenhouse gas balance and identifying mitigation options in smallholder farming systems

open access: yesEnvironmental Research Letters, 2013
Globally, agriculture is directly responsible for 14% of annual greenhouse gas (GHG) emissions and induces an additional 17% through land use change, mostly in developing countries (Vermeulen et al 2012).
T S Rosenstock   +3 more
doaj   +1 more source

Construct-level predictive validity of educational attainment and intellectual aptitude tests in medical student selection: meta-regression of six UK longitudinal studies [PDF]

open access: yes, 2013
Background: Measures used for medical student selection should predict future performance during training. A problem for any selection study is that predictor-outcome correlations are known only in those who have been selected, whereas selectors need to ...
Admissions to Higher Education Steering Group   +71 more
core   +5 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Obesogenic Environmental Influences on Young Adults: Evidence From Randomized Dormitory Assignment [PDF]

open access: yes, 2014
This study utilizes a natural experiment—conditionally random dormitory assignments of first-year US college students—to investigate the influence of obesogenic environmental factors in explaining changes in weight and exercise behavior during the 2009 ...
Eisenberg, Daniel   +2 more
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

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