Results 101 to 110 of about 1,349,118 (267)

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Preventing recurrence of endometriosis-related pain by means of long-acting progestogen therapy: the PRE-EMPT RCT

Health Technology Assessment
Background Endometriosis affects 1 in 10 women, many of whom have surgery for persistent pain. Recurrence of symptoms following an operation is common.
Kevin G Cooper, Siladitya Bhattacharya, Jane P Daniels, Versha Cheed, Laura Gennard, Lisa Leighton, Danielle Pirie, Melyda Melyda, Mark Monahan, Annalise Weckesser, Tracy Roberts, Elaine Denny, Laura Ocansey, Clive Stubbs, Emma Cox, Georgina Jones, T Justin Clark, Ertan Saridogan, Janesh K Gupta, Hilary OM Critchley, Andrew Horne, Lee J Middleton   +21 more
doaj   +1 more source

Using Semantic Ambiguity Instruction to Improve Third Graders\u27 Metalinguistic Awareness and Reading Comprehension: An Experimental Study [PDF]

, 2009
An experiment examined whether metalinguistic awareness involving the detection of semantic ambiguity can be taught and whether this instruction improves students\u27 reading comprehension.
Cairns, Helen Smith, Ehri, Linnea C., Zipke, Marcy   +2 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Optimal provision of opiate substitution therapy and needle and syringe programmes: a multi-method realist evaluation

Health Technology Assessment
Background The barriers and facilitators to engagement with Opiate Substitute Treatment and Needle and Syringe Provision need to be better understood to develop interventions to attract people into services.
Peter McCulloch, April Shaw, Gail Gilchrist, Catriona Matheson, Margaret Maxwell, Joanne Neale, Gareth Myring, Hugh McLeod, Matt Hickman, Peter Vickerman, Alison Munro, Steve MacGillivray   +11 more
doaj   +1 more source

The Impact of State Fiscal Policy on States\u27 Resilience Entering the Great Recession [PDF]

, 2019
The U.S. economy entered the Great Recession in December 2007 and exited in June 2009. This national statistic obscures a wealth of state-level data shedding light on the policies and conditions that helped some states withstand that recessionary shock ...
Paulson Gjerde, Kathy A., Prescott, Peter, Rice, Jennifer   +2 more
core   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Effects and costs of a group-based educational intervention to reduce opioid use in people with chronic pain: I-WOTCH RCT

Health Technology Assessment
Background The long-term use of strong opioids for chronic non-cancer pain puts people at risk of serious harm. Objectives To test the effectiveness and cost-effectiveness of a multicomponent intervention targeting opioid use for the treatment of chronic
Harbinder K Sandhu, Katie Booth, Sheeja Manchira Krishnan, Charles Abraham, Sharisse Alleyne, Shyam Balasubramanian, Lauren Betteley, Tom Bromilow, Dawn Carnes, Andrea D Furlan, Vijay S Gc, Kirstie L Haywood, Maddy Hill, Cynthia P Iglesias-Urrutia, Ranjit Lall, Andrea Manca, Dipesh Mistry, Joe WE Moss, Sian Newton, Vivien P Nichols, Jennifer Noyes, Emma Padfield, Anisur Rahman, Kate Seers, Jane Shaw, Nicole KY Tang, Stephanie JC Taylor, Colin Tysall, Martin Underwood, Sam Eldabe   +29 more
doaj   +1 more source

Taxation of Road Goods Vehicles – An Economic Assessment [PDF]

, 1988
This paper reviews the current position, recent research and potential future areas of research relating to road track costs, with particular reference to Heavy Goods Vehicles.
Fowkes, A.S., Nash, C.A., Tweddle, G.
core