Results 121 to 130 of about 361,322 (325)
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Bayesian and non-Bayesian estimation of some entropy measures for a Weibull distribution
AIMS MathematicsEntropy measures have been employed in various applications as a helpful indicator of information content. This study considered the estimation of Shannon entropy, $ \zeta $-entropy, Arimoto entropy, and Havrda and Charvat entropy measures for the ...
Amal S. Hassan +3 more
doaj +1 more source
The analogues of entropy and of Fisher's information measure in free probability theory [PDF]
Inventiones Mathematicae, 1993 In Part I [Commun. Math. Phys. 155, No. 1, 71-92 (1993; Zbl 0781.60006)] we studied the free entropy \(\Sigma(X)\) of a self-adjoint random variable \(X\) equal to minus the logarithmic energy of its distribution. We also introduced a generalization \(\Sigma(X_ 1,\dots, X_ n)\) which, however, does not have the necessary properties for \(n \geq 2\) to ...
openaire +4 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Linguistic hesitant intuitionistic fuzzy cross-entropy measures
International Journal of Computational Intelligence Systems, 2017 In this paper, several cross-entropy measures for linguistic hesitant intuitionistic fuzzy information have been developed which integrating cross-entropy measures of intuitionistic fuzzy sets and hesitant fuzzy linguistic sets. Some desirable properties
Wei Yang, Yongfeng Pang, Jiarong Shi
doaj +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source