Results 61 to 70 of about 345,393 (288)

A unified framework for information integration based on information geometry

, 2015
We propose a unified theoretical framework for quantifying spatio-temporal interactions in a stochastic dynamical system based on information geometry.
Amari, Shun-ichi, Oizumi, Masafumi, Tsuchiya, Naotsugu   +2 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Structural Information in Two-Dimensional Patterns: Entropy Convergence and Excess Entropy

, 2002
We develop information-theoretic measures of spatial structure and pattern in more than one dimension. As is well known, the entropy density of a two-dimensional configuration can be efficiently and accurately estimated via a converging sequence of ...
A. Lempel, A.G. Schlijper, A.G. Schlijper, A.G. Schlijper, A.N. Pavlov, B. Baumgartner, C. Andraud, C. Andraud, C.D.Van Siclen, D. Arnold, D. Sheinwald, D.P. Feldman, D.P. Varn, David P. Feldman, E. Olbrich, E. Soljanin, E.M. Sal’nikova, H. Meirovitch, H. Meirovitch, H. Meirovitch, H. Meirovitch, H. Meirovitch, J.D. Farmer, J.L. McCauley, J.P. Crutchfield, J.P. Crutchfield, J.P. Crutchfield, J.P. Crutchfield, J.P. Crutchfield, James P. Crutchfield, K. Lindgren, K. Lindgren, K. Young, P. Grassberger, P.-M. Binder, R. Piasecki, R. Piasecki, R. Piasecki, R.L.C. Vink, S. Goldstein, S. Marcelja, T. Schürmann, V. Spirin, V. Spirin, W. Bialek, W. Ebeling, W. Li, Y.A. Andrienko, Z. Alexandrowicz, Z. Alexandrowicz   +49 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Entropy of Neuronal Spike Patterns

Entropy
Neuronal spike patterns are the fundamental units of neural communication in the brain, which is still not fully understood. Entropy measures offer a quantitative framework to assess the variability and information content of these spike patterns.
Artur Luczak
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

A Generalized Relative (α, β)-Entropy: Geometric Properties and Applications to Robust Statistical Inference

Entropy, 2018
Entropy and relative entropy measures play a crucial role in mathematical information theory. The relative entropies are also widely used in statistics under the name of divergence measures which link these two fields of science through the minimum ...
Abhik Ghosh, Ayanendranath Basu
doaj   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source