Results 91 to 100 of about 6,806,810 (337)
A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins
FEBS Letters, EarlyView.We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue +6 more
wiley +1 more source
Single cell mechanics: stress stiffening and kinematic hardening
, 2007 Cell mechanical properties are fundamental to the organism but remain poorly understood. We report a comprehensive phenomenological framework for the nonlinear rheology of single fibroblast cells: a superposition of elastic stiffening and viscoplastic ...
A. Mogilner +10 more
core +1 more source
Methods Used to Evaluate Pain Behaviors in Rodents
Frontiers in Molecular Neuroscience, 2017 Rodents are commonly used to study the pathophysiological mechanisms of pain as studies in humans may be difficult to perform and ethically limited.
Jennifer R. Deuis +3 more
doaj +1 more source
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Mechanical thermal motor [PDF]
, 1976 An apparatus is described for converting thermal energy such as solar energy into mechanical motion for driving fluid pumps and similar equipment. The thermal motor comprises an inner concentric cylinder carried by a stationary core member.
Hein, L. A., Myers, W. N.
core +1 more source
Probing the mechanical properties of graphene using a corrugated elastic substrate
, 2010 The exceptional mechanical properties of graphene have made it attractive for nano-mechanical devices and functional composite materials. Two key aspects of graphene's mechanical behavior are its elastic and adhesive properties.
Cesar Chialvo +8 more
core +1 more source
Journal of Asian Ceramic Societies, 2019 This paper reports on a study of the effects of nano-alumina on the structural, mechanical and thermal properties of geopolymer matrices. Sample composites were produced by mixing metakaolin, an alkaline solution and nano-alumina (1%, 2% and 3%) with a ...
Z. Zidi +3 more
doaj +1 more source
Hematopoietic (stem) cells—The elixir of life?
FEBS Letters, EarlyView.The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo +4 more
wiley +1 more source
Mechanical actuator Patent [PDF]
, 1969 Mechanical actuator wherein linear motion changes to rotational ...
Johnson, J. C., Jr.
core +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source