Results 131 to 140 of about 899,308 (256)

A modular spring-loaded actuator for mechanical activation of membrane proteins. [PDF]

Nat Commun, 2022
Mills A, Aissaoui N, Maurel D, Elezgaray J, Morvan F, Vasseur JJ, Margeat E, Quast RB, Lai Kee-Him J, Saint N, Benistant C, Nord A, Pedaci F, Bellot G.   +13 more
europepmc   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Mechanical Activation of Forbidden Photoreactivity in Oxa-di-π-methane Rearrangement. [PDF]

J Org Chem, 2022
Jodra A, García-Iriepa C, Frutos LM.
europepmc   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

A mathematical model for mechanical activation and compound action potential generation by the utricle in response to sound and vibration. [PDF]

Front Neurol, 2023
Pastras CJ, Gholami N, Jennings S, Zhu H, Zhou W, Brown DJ, Curthoys IS, Rabbitt RD.   +7 more
europepmc   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Motion lubrication suppressed mechanical activation via hydrated fibrous gene patch for tendon healing. [PDF]

Sci Adv, 2023
Xiang L, Liang J, Wang Z, Lin F, Zhuang Y, Saiding Q, Wang F, Deng L, Cui W.   +8 more
europepmc   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Effect of Mechanical Activation and High Pressure High Temperature Treatment on Synthesis of Material Based on Nanostructured Boron Nitride

Механика машин, механизмов и материалов, 2019
In the paper, the study of the influence of mechanical activation (MA) and subsequent high pressure high temperature (HPHT) treatment of the powder of hexagonal boron nitride (hBN) on its structure and phase composition is given.
Vladimir T. Senyut, Svetlana A. Kovaliova, Igor V. Val’kovich , Viktor I. Zhornik, Wensheng Li, Cheng Bo, Dongqing He , Haimin Zhai   +7 more
doaj  

Mechanical activation with Easy Clean device enhanced organic tissue removal from simulated internal root resorption in a laboratory evaluation. [PDF]

BMC Oral Health, 2023
Monteiro LPB, de Sousa SEM, de Castro RF, da Silva EJNL, da Silva Brandão JM.   +4 more
europepmc   +1 more source