Results 181 to 190 of about 899,308 (256)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Modeling mechanical activation of macrophages during pulmonary fibrogenesis for targeted anti-fibrosis therapy. [PDF]

Sci Adv
Xu Y, Ying L, Lang JK, Hinz B, Zhao R.
europepmc   +1 more source

Study of the Influence of Sintering Atmosphere and Mechanical Activation on the Synthesis of Bulk Ti₂AlN MAX Phase Obtained by Spark Plasma Sintering. [PDF]

Materials (Basel), 2021
Salvo C, Chicardi E, García-Garrido C, Poyato R, Jiménez JA, Mangalaraja RV.   +5 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Polymer time crystal: Mechanical activation of reversible bonds by low-amplitude high frequency excitations. [PDF]

Sci Adv
Heidari M, Gaichies T, Leibler L, Labousse M.   +3 more
europepmc   +1 more source

Kindlin-2 Mediates Mechanical Activation of Cardiac Myofibroblasts. [PDF]

Cells, 2020
Godbout E, Son DO, Hume S, Boo S, Sarrazy V, Clément S, Kapus A, Wehrle-Haller B, Bruckner-Tuderman L, Has C, Hinz B.   +10 more
europepmc   +1 more source

Effect of Mechanical Activation of Al-Ti-B Powder Mixture on Phase Composition and Structure of Al-TiB₂ Composite Materials Obtained by Self-Propagating High-Temperature Synthesis (SHS). [PDF]

Materials (Basel), 2022
Matveev A, Promakhov V, Nikitin P, Babaev A, Vorozhtsov A.   +4 more
europepmc   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

MULTIMODAL LEARNING TO IMPROVE CARDIAC LATE MECHANICAL ACTIVATION DETECTION FROM CINE MR IMAGES. [PDF]

Proc IEEE Int Symp Biomed Imaging
Xing J, Wu N, Bilchick KC, Epstein FH, Zhang M.   +4 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source