Results 181 to 190 of about 898,493 (283)

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Enhanced Leaching of Lepidolite by Acidophilic Microorganisms Under Mechanical Activation. [PDF]

Microorganisms
Li J, Wang M, Zhang R, Liu H, Huang S, Liu Y, Liao R, Vardanyan A, Xia J, Wang J.   +9 more
europepmc   +1 more source

Targeting the latest site of left ventricular mechanical activation is associated with improved long-term outcomes for recipients of cardiac resynchronization therapy. [PDF]

Heart Rhythm O2, 2022
Borgquist R, Barrington WR, Bakos Z, Werther-Evaldsson A, Saba S.   +4 more
europepmc   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Mechanical Activation of cPLA2 Impedes Fatty Acid β-Oxidation in Vein Grafts. [PDF]

Adv Sci (Weinh)
Fan L, Tang Y, Liu J, Liu Y, Xu Y, Liu J, Liu H, Pang W, Guo Y, Yao W, Zhang T, Peng Q, Zhou J.   +12 more
europepmc   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

SCAR-AWARE LATE MECHANICAL ACTIVATION DETECTION NETWORK FOR OPTIMAL CARDIAC RESYNCHRONIZATION THERAPY PLANNING. [PDF]

Proc IEEE Int Symp Biomed Imaging
Xing J, Wang S, Patel AR, Bilchick KC, Epstein FH, Zhang M.   +5 more
europepmc   +1 more source

Mechanical activation of the angiotensin II type 1 receptor contributes to abdominal aortic aneurysm formation. [PDF]

JVS Vasc Sci, 2021
Hall S, Ward ND, Patel R, Amin-Javaheri A, Lanford H, Grespin RT, Couch C, Xiong Y, Mukherjee R, Jones JA, Ruddy JM.   +10 more
europepmc   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Outcomes of Cardiac Resynchronization Therapy with Image-Guided Left Ventricular Lead Placement at the Site of Latest Mechanical Activation: A Systematic Review and Meta-Analysis. [PDF]

J Interv Cardiol, 2022
Allen LaPointe NM, Ali-Ahmed F, Dalgaard F, Kosinski AS, Schmidler GS, Al-Khatib SM.   +5 more
europepmc   +1 more source