Results 11 to 20 of about 898,493 (283)
Activation mechanism of PINK1 [PDF]
Nature, 2021 Mutations in the protein kinase PINK1 lead to defects in mitophagy and cause autosomal recessive early onset Parkinson's disease1,2. PINK1 has many unique features that enable it to phosphorylate ubiquitin and the ubiquitin-like domain of Parkin3-9.
Zhong Yan Gan +11 more
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Radion-activated Higgs mechanism [PDF]
Physical Review D, 2020 We study multi-scalar models of radius stabilization, with an eye towards application to novel extra-dimensional models of symmetry breaking. With inspiration from holography, we construct a multi-scalar effective potential that is a function of UV-brane values of the scalar fields, and that takes into account bulk gravitational backreaction.
Cem Eröncel, Jay Hubisz, Gabriele Rigo
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Lagrangian mechanics of active systems [PDF]
The European Physical Journal E, 2021 Abstract We present a multi-scale modeling and simulation framework for low-Reynolds number hydrodynamics of shape-changing immersed objects, e.g., biological microswimmers and active surfaces. The key idea is to consider principal shape changes as generalized coordinates and define conjugate generalized hydrodynamic ...
Solovev, Anton, Friedrich, Benjamin M.
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Current Opinion in Physiology, 2020 Store-operated calcium entry (SOCE) through Orai ion channels is an intracellular signaling pathway that is initiated by ligand-induced depletion of calcium from the endoplasmic reticulum (ER) store. The molecular link between SOCE and ER store depletion is thereby provided by a distinct class of single pass ER transmembrane proteins known as stromal ...
Fahrner, Marc +2 more
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Mechanisms of TLR9 activation [PDF]
Journal of Endotoxin Research, 2004 Non-methylated CpG-motifs in bacterial or viral DNA are recognized by TLR9 as foreign. The activation of TLR9 by microbial DNA or synthetic oligonucleotides based on these motifs leads to the induction of innate immune responses. We have compared the subcellular localization of fluorescent versions of TLR9 and TLR4 and found that TLR9 is expressed in ...
Eicke, Latz +3 more
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Role of acid-base interactions in synthesis of cordierite from talc and sillimanite group minerals [PDF]
Science of Sintering, 2013 It has been found that the mechanical activation of mixtures of sillimanite group minerals with talc and silica additives in grinding-activating devices with periodic and flow action provides significant acceleration of their interaction with ...
Avvakumov E.G. +3 more
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Mechanically Activated Ion Channels [PDF]
Neuron, 2015 Mechanotransduction, the conversion of physical forces into biochemical signals, is essential for various physiological processes such as the conscious sensations of touch and hearing, and the unconscious sensation of blood flow. Mechanically activated (MA) ion channels have been proposed as sensors of physical force, but the identity of these channels
Ranade, Sanjeev S. +2 more
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Relaxation dynamics of Fe55Cr10Mo14C15B6 metallic glass explored by mechanical spectroscopy and calorimetry measurements [PDF]
, 2016 In this work, the mechanical relaxation dynamics of Fe55Cr10Mo14C15B6 metallic glass is explored by mechanical spectroscopy. The temperature-dependent loss modulus E″(T) shows the features of β relaxation well below glass transition temperature Tg.
Crespo Artiaga, Daniel +3 more
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Transcriptional activators and activation mechanisms [PDF]
Protein & Cell, 2007 Transcriptional activators are required to turn on the expression of genes in a eukaryotic cell. Activators bound to the enhancer can facilitate either the recruitment of RNA polymerase II to the promoter or its elongation. This article examines a few selected issues in understanding activator functions and activation mechanisms.
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Electrical properties of mechanically activated zinc oxide [PDF]
Science of Sintering, 2006 Microstructural properties of a commercial zinc oxide powder were modified by mechanical activation in a high-energy vibro-mill. The obtained powders were dry pressed and sintered at 1100°C for 2 h.
Vojisavljević K. +3 more
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