Results 41 to 50 of about 915,324 (354)
Increasing β-catenin/Wnt3A activity levels drive mechanical strain-induced cell cycle progression through mitosis. [PDF]
, 2016 Mechanical force and Wnt signaling activate β-catenin-mediated transcription to promote proliferation and tissue expansion. However, it is unknown whether mechanical force and Wnt signaling act independently or synergize to activate β-catenin signaling ...
Benham-Pyle, Blair W +4 more
core +2 more sources
Modulation of sensory neuron mechanotransduction by PKC- and nerve growth factor-dependent pathways [PDF]
, 2006 Many sensations of pain are evoked by mechanical stimuli, and in inflammatory conditions, sensitivity to such stimuli is commonly increased. Here we used cultured sensory neurons as a model of the peripheral terminal to investigate the effects of ...
DI CASTRO, MARIA AMALIA +3 more
core +1 more source
Mechanisms of Viral Activators
Cold Spring Harbor Symposia on Quantitative Biology, 1998 Adenovirus large E1A, Epstein-Barr virus Zebra, and herpes simplex virus VP16 were studied as models of animal cell transcriptional activators. Large E1A can activate transcription from a TATA box, a result that leads us to suggest that it interacts with a general transcription factor.
Berk, A +9 more
openaire +3 more sources
The mechanism of mRNA activation
, 2023 Summary During translation initiation, messenger RNA molecules must be identified and activated for loading into a ribosome. In this rate-limiting step, the heterotrimeric protein eukaryotic initiation factor eIF4F must recognize and productively interact with the 7-methylguanosine cap at the 5’ end of the messenger RNA and subsequently
Riley C. Gentry +5 more
openaire +2 more sources
Mechanisms of Opsin Activation [PDF]
Journal of Biological Chemistry, 1996 Rhodopsin is constrained in an inactive conformation by interactions with 11-cis-retinal including formation of a protonated Schiff base with Lys296. Upon photoisomerization, major structural rearrangements that involve protonation of the active site Glu113 and cytoplasmic acidic residues, including Glu134, lead to the formation of the active form of ...
J, Buczyłko +3 more
openaire +2 more sources
Bioactive glass-ceramic scaffolds from novel 'inorganic gel casting' and sinter-crystallization [PDF]
, 2017 Highly porous wollastonite-diopside glass-ceramics have been successfully obtained by a new gel-casting technique. The gelation of an aqueous slurry of glass powders was not achieved according to the polymerization of an organic monomer, but as the ...
Bernardo, Enrico +5 more
core +2 more sources
Closing in on a mechanism for activation
eLife, 2014 When insulin-like growth factor-1 (IGF1) binds to its receptor, a physical constraint is released that allows the two transmembrane helices to come together to facilitate activation of the receptor.
Stevan R Hubbard, W Todd Miller
openaire +3 more sources
Current Opinion in Physiology, 2020 Store-operated calcium entry (SOCE) through Orai ion channels is an intracellular signaling pathway that is initiated by ligand-induced depletion of calcium from the endoplasmic reticulum (ER) store. The molecular link between SOCE and ER store depletion is thereby provided by a distinct class of single pass ER transmembrane proteins known as stromal ...
Fahrner, Marc +2 more
openaire +3 more sources
Mathematical modeling of the mechanical characteristic of the activated PTFE-matrix using the method of planning the experiment [PDF]
Журнал інженерних наук, 2018 In this paper, the influence of the parameters of the technological process of mechanical activation on the physical characteristics of the polytetrafluoroethylene (PTFE) matrix is investigated.
Bilous O. A. +4 more
doaj +1 more source
Acoustic Tweezing Cytometry Induces Rapid Initiation of Human Embryonic Stem Cell Differentiation. [PDF]
, 2018 Mechanical forces play critical roles in influencing human embryonic stem cell (hESC) fate. However, it remains largely uncharacterized how local mechanical forces influence hESC behavior in vitro.
Deng, Cheri X +8 more
core +2 more sources