Results 71 to 80 of about 163,939 (298)

Comparable outcomes with a potential functional advantage of PCL preservation in medial‐stabilized total knee arthroplasty: A systematic review and meta‐analysis from the FP‐UCBM Knee Study Group

Journal of Experimental Orthopaedics
Purpose The management of the posterior cruciate ligament (PCL) in medial‐stabilized (MS) total knee arthroplasty (TKA) remains a topic of debate.
Augusto Ferrini, Giuseppe Francesco Papalia, Giancarlo Giurazza, Andrea Tanzilli, Pietro Gregori, Edoardo Franceschetti, Rocco Papalia, Stefano Campi   +7 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Coronal Plane Alignment of the Knee Classification and Its Correlation with Post-operative Functional Outcomes in Total Knee Arthroplasty: A Prospective Cohort Study

Journal of Orthopaedic Case Reports
Introduction: Total knee arthroplasty (TKA) is widely performed for end-stage osteoarthritis; however, 15–20% of patients continue to experience dissatisfaction despite successful surgery.
Siddharth Malik, Gourab Biswas, Nithin Sundaresan, Sitansu Sekhar Samantaray, Akash Pradip Bera, Hunaid Zoeb Haider   +5 more
doaj   +1 more source

A prospective randomised control trial comparing functional with mechanical axis alignment in total knee arthroplasty: study protocol for an investigator initiated trial

Trials, 2021
Background A drive to improve functional outcomes for patients undergoing total knee arthroplasty (TKA) has led to alternative alignment being used. Functional alignment (FA) uses intraoperative soft tissue tension to determine the optimal position of ...
Richard Steer, Beth Tippett, R. Nazim Khan, Dermot Collopy, Gavin Clark   +4 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

New Insights into the Mechanism for Chromosome Alignment in Metaphase [PDF]

, 2013
During mitosis, duplicated sister chromatids are properly aligned at the metaphase plate of the mitotic spindle before being segregated into two daughter cells. This requires a complex process to ensure proper interactions between chromosomes and spindle microtubules. The kinetochore, the proteinaceous complex assembled at the centromere region on each
Yige, Guo, Christine, Kim, Yinghui, Mao
openaire   +2 more sources

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

No difference in postoperative patient satisfaction rates between mechanical and kinematic alignment total knee arthroplasty: A systematic review

Journal of Experimental Orthopaedics
Purpose The purpose of this systematic review was to compare patient satisfaction patient‐reported outcomes (PROMs) levels after mechanically aligned (MA) and kinematically aligned (KA) total knee arthroplasty (TKA).
Zainab‐Aqeel Khan, Alexandra Leica, Manuel‐Paul Sava, Michael T. Hirschmann   +3 more
doaj   +1 more source

A retrospective study of articular surface mounting computer-assisted total knee arthroplasty in alignment, knee function, and survival

Journal of Orthopaedics, Trauma and Rehabilitation, 2023
Background Hong Kong Chinese exhibits a greater varus lower limb mechanical axis and coronal bowing when compared to Caucasians. This anatomical difference may affect the accuracy of bone cuts in total knee arthroplasty (TKA) using western anatomy-based ...
Eugene Pak-Lin Ng, Hing-Cheong Wong
doaj   +1 more source