Results 81 to 90 of about 163,939 (298)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

How often do we alter constitutional limb alignment, joint line obliquity, and Coronal Plane Alignment of the Knee (CPAK) phenotype when performing mechanically aligned TKA?: a large single-institution retrospective radiological analysis

Bone & Joint Open
Aims: While mechanical alignment (MA) is the traditional technique in total knee arthroplasty (TKA), its potential for altering constitutional alignment remains poorly understood.
Luke E. Corban, Victor A. van de Graaf, Darren B. Chen, Jil A. Wood, Ashish D. Diwan, Samuel J. MacDessi   +5 more
doaj   +1 more source

Short-term functional outcomes of robotic-assisted TKA are better with functional alignment compared to adjusted mechanical alignment. [PDF]

SICOT J
Introduction: Ligament balancing is essential to the functional outcome of total knee arthroplasty (TKA). The optimal method of alignment remains a controversial issue.
Jeffrey M, Marchand P, Kouyoumdjian P, Coulomb R.   +3 more
europepmc   +2 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Posterior condylar offset and clinical outcomes in medial pivot total knee arthroplasty: A comparison of mechanical and kinematic alignment

Journal of Experimental Orthopaedics
Purpose The purpose of this study was to compare preservation of posterior condylar offset (PCO) and posterior condylar offset ratio (PCOR) after medial pivot (MP) total knee arthroplasty (TKA) performed with kinematic (KA) or mechanical alignment (MA ...
Amir Koutp, Konstanze Huetter, Rene Schroedter, Lukas Leitner, Andreas Leithner, Patrick Sadoghi   +5 more
doaj   +1 more source

The immediate post-operative radiograph is an unreliable measure of coronal plane alignment in total knee replacement.

Frontiers in Surgery, 2014
Background - Restoration of a neutral mechanical axis is a primary goal of total knee replacement (TKR). A mechanical axis within three degrees of neutral has been correlated with improved implant longevity, function and patient satisfaction.
Joshua ePetterwood, Joshua ePetterwood, Michelle M Dowsey, Michelle M Dowsey, Daevyd eRodda, Daevyd eRodda, Peter F. Choong, Peter F. Choong   +7 more
doaj   +1 more source

The opto-mechanical alignment procedure of the VLT Survey Telescope

, 2010
The VLT Survey Telescope is a f/5.5 modified Ritchey-Chretien imaging telescope, which is being installed at the ESO-Paranal Observatory. It will provide a one square degree corrected field of view to perform surveyprojects in the wavelength range from ...
Ragazzoni R., Arcidiacono C., Umbriaco G., Magrin D., Farinato J.   +4 more
core   +1 more source

High Performance Biological Pairwise Sequence Alignment: FPGA versus GPU versus Cell BE versus GPP [PDF]

, 2012
This paper explores the pros and cons of reconfigurable computing in the form of FPGAs for high performance efficient computing. In particular, the paper presents the results of a comparative study between three different acceleration technologies ...
Liu, Ying, Yang Song, Akoglu, Ali, Xiang Tian, Ying Liu, Ali Akoglu, Benkrid, Khaled, Cheng Ling, Khaled Benkrid, Song, Yang, Ling, Cheng, Tian, Xiang   +11 more
core   +1 more source