Results 31 to 40 of about 8,976,807 (249)

Viscoelastic Testing in Pediatric Mechanical Circulatory Support

Frontiers in Medicine, 2022
Pediatric mechanical circulatory support can be lifesaving. However, managing anticoagulation is one of the most challenging aspects of care in patients requiring mechanical circulatory support.
Katherine Regling, Arun Saini, Katherine Cashen   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The European Registry for Patients with Mechanical Circulatory Support (EUROMACS): first annual report [PDF]

, 2015
The European Registry for Patients with Mechanical Circulatory Support (EUROMACS) was founded on 10 December 2009 with the initiative of Roland Hetzer (Deutsches Herzzentrum Berlin, Berlin, Germany) and Jan Gummert (Herz- und Diabeteszentrum Nordrhein ...
Krabatsch, Thomas, Netuka, Ivan, Bushnaq, Hasan, Zittermann, Armin, Potapov, Evgenij, Martinelli, Luigi, EUROMACS members, Mohacsi, Paul, de By, Theo M M H, Leprince, Pascal, Delmo Walter, Eva Maria, Hetzer, Roland, de By, Theo M.MH., Bendjelid, Karim, Gummert, Jan, Gustafsson, Finn, Meyns, Bart, Morshuis, Michiel   +17 more
core   +2 more sources

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Portable (short-term) mechanical circulatory support

, 2018
Mechanical circulatory support can be used to resuscitate patients, as a stabilizing measure for angiography and prompt revascularization, or to buy time until more definite measures can be taken.
Susanna Price, Pascal Vranckx
core   +1 more source

Accuracy of the HeartMate 3 Left Ventricular Assist Device Flow Estimation

Scientific Reports
Left ventricular assist devices (LVADs), such as the HeartMate 3 (HM3), are a treatment option for advanced heart failure (HF). Non-invasive monitoring of heart-pump interaction is crucial but relies on estimated parameters only.
Theodor Abart, Marko Grujic, Philipp Aigner, Michael Röhrich, Stefan Jakubek, Daniel Zimpfer, Marcus Granegger   +6 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Determination of Brain Death in Patients Undergoing Short-Term Mechanical Circulatory Support Devices

, 2021
Objective: To describe apnoea test (AT) and ancillary study performance for brain death (BD) determination among patients undergoing short-term mechanical circulatory support (MCS) devices, including extracorporeal membrane oxygenation (ECMO) and intra ...
Cho, SM, Migdady, I, Amin, M, George, P, Shoskes, A, Rae-Grant, A   +5 more
core   +1 more source

Impact of adjustable resistance clamps on the in-vitro hemolysis assessment of blood pumps

Scientific Reports
Adjustable resistance clamps are essential to regulate flow and pressure in in-vitro test loops designed to evaluate hemolysis in blood pumps. However, their contribution to overall hemolysis remains unclear.
Krishnaraj Narayanaswamy, Xiangyu He, Leonie Schmitt, Martin Stoiber, Michael Röhrich, Daniel Zimpfer, Marcus Granegger   +6 more
doaj   +1 more source