Results 51 to 60 of about 115,505 (280)

Neural regulation of cardiovascular response to exercise: role of central command and peripheral afferents [PDF]

, 2014
During dynamic exercise, mechanisms controlling the cardiovascular apparatus operate to provide adequate oxygen to fulfill metabolic demand of exercising muscles and to guarantee metabolic end-products washout.
Crisafulli, A, Marongiu, E, Nobrega, ACL, O'Leary, D, Piepoli, MF, Silva, BM   +5 more
core   +4 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Extracorporeal life support devices and strategies for management of acute cardiorespiratory failure in adult patients: A comprehensive review [PDF]

, 2014
Evolution of extracorporeal life support (ECLS) technology has added a new dimension to the intensive care management of acute cardiac and/or respiratory failure in adult patients who fail conventional treatment.
Fraser, John F., Mullany, Daniel V., Platts, David G., Shekar, Kiran, Thomson, Bruce, Ziegenfuss, Marc   +5 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Three-year outcomes with the use of dual non-invasive rejection surveillance after heart transplantation

JHLT Open
Background: Donor-derived cell-free DNA (ddcfDNA) and gene expression profiling (GEP) allow for non-invasive monitoring of rejection after heart transplantation in place of endomyocardial biopsies (EMBx).
Erik J. Henricksen, PharmD, Juka S. Kim, MD, Kiran K. Khush, MD, MAS, Joyce Njoroge, Helen Luikart, RN, MSN, Melody B. Zhang, MD, Roy Lee, PharmD, Thu Le, PharmD, Brandon A. Guenthart, MD, Jeffrey J. Teuteberg, MD   +9 more
doaj   +1 more source

Women in mechanical circulatory support: She persisted!

Frontiers in Cardiovascular Medicine, 2022
Many women physicians have blazed trails and played instrumental roles in advancing the field of Advanced Heart Failure (AHF), Mechanical Circulatory Support (MCS), and cardiac transplantation to its current recognition and glory.
Kelley N. Benck, Fatima A. Khan, Mrudula R. Munagala   +2 more
doaj   +1 more source

Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine. [PDF]

, 2014
OBJECTIVE: Circulatory shock is a life-threatening syndrome resulting in multiorgan failure and a high mortality rate. The aim of this consensus is to provide support to the bedside clinician regarding the diagnosis, management and monitoring of shock.
A Babaev, A Bourgoin, A Combes, A Dubin, A Geppert, A Gestel van, A Perel, A Perel, A Rhodes, A Vieillard-Baron, A Vieillard-Baron, A Vieillard-Baron, A Vieillard-Baron, AE Jones, AF Connors Jr, Alexandre Mebazaa, AM Schulman, Andrew Rhodes, AP Wheeler, AS Beraud, B Bouhemad, B Lamia, B Vallet, BP Cholley, BR Soller, C Alberti, C Brun-Buisson, C Brun-Buisson, C Brun-Buisson, C Pierrakos, CA Polanczyk, Christoph Hofer, CI Pro, D Annane, D Atkins, D Backer De, D Backer De, D Backer De, D Backer De, D Backer De, D Fagnoul, D LeDoux, Daniel De Backer, DR Holmes Jr, E Kupersztych-Hagege, E Rivers, E Silva, EP Rivers, F Boissier, F Michard, F Michard, F Vallee, G Friedman, G Hernandez, G Lheritier, G Marecaux, G Tachon, GA Wanner, H Flaatten, H Zhang, H Zhang, HB Nguyen, HH Awad, I Jawad, I Salvo, I Werra de, J Bakker, J Bakker, J Creteur, J Maizel, J Mesquida, Jan Bakker, JB Hall, JD Ricard, Jean Louis Teboul, Jean Louis Vincent, JH McGowan, JJ Ronco, JL Teboul, JL Vanoverschelde, JL Vincent, JL Vincent, JL Vincent, JL Vincent, JL Vincent, JP Quenot, JP Revelly, K Bouferrache, L Jacquet, M Antonelli, M Cannesson, M Cecconi, M Cecconi, M Cecconi, M Feissel, M Howell, M Pinsky, MA Hayes, Massimo Antonelli, Maurizio Cecconi, ME Genderen van, ME Genderen van, ME Hands, ME Mikkelsen, MH Weil, MH Weil, MI Monge Garcia, MI Monge Garcia, Michael R. Pinsky, MR Pinsky, MR Shah, NJ Ekbal, O Godje, O Hamzaoui, O Taton, P Asfar, P Asfar, P Vignon, P Wacharasint, PE Marik, PT O’Gara, RA Linton, Richard Beale, RJ Goldberg, RJ Goldberg, Roman Jaeschke, RP Dellinger, RS Hotchkiss, S Harvey, S Heenen, S Magder, S Magder, S Magder, S Magder, S Marque, S Trzeciak, SA Stern, SD Murdoch, SF Nagueh, SG Sakka, SM Cain, SR Ommen, TC Jansen, TC Jansen, TC Jansen, TC Jansen, VS Edul, WH Bickell, WT Linde-Zwirble, X Monnet, X Monnet, X Monnet, X Monnet, X Monnet, X Monnet, X Monnet, Y Sakr, Y Sakr   +157 more
core   +5 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Temporary Mechanical Circulatory Support: A Review of the Options, Indications, and Outcomes

Clinical Medicine Insights: Cardiology, 2014
Cardiogenic shock remains a challenging disease entity and is associated with significant morbidity and mortality. Temporary mechanical circulatory support (MCS) can be implemented in an acute setting to stabilize acutely ill patients with cardiomyopathy
Nisha A. Gilotra, Gerin R. Stevens
doaj   +1 more source