Results 41 to 50 of about 8,976,807 (249)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Rotary mechanical circulatory support systems

Journal of Rehabilitation and Assistive Technologies Engineering, 2017
A detailed survey of the current trends and recent advances in rotary mechanical circulatory support systems is presented in this paper. Rather than clinical reports, the focus is on technological aspects of these rehabilitating devices as a reference ...
Milad Hosseinipour, Rajesh Gupta, Mark Bonnell, Mohammad Elahinia   +3 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Hemodynamics of Prolonged Percutaneous Mechanical Circulatory Support – When Vasodilatation Sets [PDF]

, 2022
Hemodynamics play an important role in cardiogenic shock assessment for prognosis estimation and for phenotyping cardiogenic shock. This is best done by pulmonary artery catheters.
Thiele, Holger
core   +1 more source

Mechanical circulatory support in patients with severe heart failure [PDF]

, 2010
Severe heart failure has a poor prognosis. Mechanical circulatory support (MCS) is capable of assisting the circulation in selected patients to bridge them to heart transplantation or recovery of heart function.
Lidén, Hans
core   +1 more source

Speech Signal Preprocessing and Feature Extraction for Biomarker Identification in Acute Heart Failure: A Pilot Study

Applied Sciences
This study presents a configurable speech signal preprocessing and feature-extraction workflow for identifying candidate acoustic biomarkers in acute heart failure. The workflow was evaluated in 12 patients hospitalized with acute heart failure.
Andrzej Majkowski, Tomasz Rywik, Paweł Irzmański, Jakub Czapnik, Marcin Kołodziej, Anna Drohomirecka   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Three-year outcomes with the use of dual non-invasive rejection surveillance after heart transplantation

JHLT Open
Background: Donor-derived cell-free DNA (ddcfDNA) and gene expression profiling (GEP) allow for non-invasive monitoring of rejection after heart transplantation in place of endomyocardial biopsies (EMBx).
Erik J. Henricksen, PharmD, Juka S. Kim, MD, Kiran K. Khush, MD, MAS, Joyce Njoroge, Helen Luikart, RN, MSN, Melody B. Zhang, MD, Roy Lee, PharmD, Thu Le, PharmD, Brandon A. Guenthart, MD, Jeffrey J. Teuteberg, MD   +9 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source