Results 111 to 120 of about 1,338,017 (303)
Analysis of damage and fracture formulations in cold extrusion [PDF]
, 2017 In forming processes, components generally undergo large deformations. This induces the evolution of damage, which can influence material and product properties.
Clausmeyer, Till +2 more
core
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Meitan xuebaoCO2 geological storage technology is one of the effective technologies for achieving carbon reduction and the reuse of abandoned mine resources. In order to reveal the interaction mechanism between supercritical CO2 and coal during injection and its ...
Baisheng NIE +7 more
doaj +1 more source
Influence of environmental conditions on the quality of potato tubers
Horticultural Science, 2005 In 1995-1997 seven varieties of potatoes were cultivated in field trials in twelve localities in the Czech Republic. Six of the twelve localities were situated in lower, warmer and drier areas with fertile, predominantly loamy soils. The other localities
K. Hamouz, J. Čepl, P. Dvořák
doaj +1 more source
Modeling anisotropic damage in elasto-plastic materials with structural defects [PDF]
, 2013 The paper deals with models for elasto-plastic materials with continuously distributed micro defects (micro cracks, micro voids, extra-matte), compatible with the principle of imbalance of the free energy.
Cleja-Tigoui, Sanda, Tigoui, Victor
core
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Revista Brasileira de Engenharia Agrícola e Ambiental, 2011 Objetivou-se com este trabalho verificar a resistência de grãos de milho a danos mecânicos via teste de impacto. Sete híbridos foram avaliados: AS1535, AS1570, AS1575, AS3430, AG7000, P30F80 e DKB390.
Dielle C. de Carvalho +4 more
doaj +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source