Results 91 to 100 of about 4,432,927 (296)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Pipeline Mechanical Damage Characterization by Multiple Magnetization Level Decoupling [PDF]
, 1999 Mechanical damage, caused by mechanical forces that deform the natural cylindrical shape of a pipe, can be detrimental to the operational integrity of a pipeline. Mechanical damage can either remain benign for the operational life of the pipeline or lead
Davis, Richard +3 more
core +1 more source
Effect of Clearance on Mechanical Damage of Processed Rice
Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2017 The effect of rubber rolls in husking machine (Yanmar type) on rice cultivars of Tarm Hashemi (TH) and Daillman Mazandarani (DM) were tested during husking at three clearances of 0.4, 0.6 and 0.8 mm between cylinders.
Salih K. Alwan Alsharifi +3 more
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Mechanism of DNA damage tolerance
World Journal of Biological Chemistry, 2015 DNA damage may compromise genome integrity and lead to cell death. Cells have evolved a variety of processes to respond to DNA damage including damage repair and tolerance mechanisms, as well as damage checkpoints. The DNA damage tolerance (DDT) pathway promotes the bypass of single-stranded DNA lesions encountered by DNA polymerases during DNA ...
openaire +2 more sources
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Machine vision evaluation of corn kernel mechanical and mold damage
, 2010 [[abstract]]Machine vision algorithms were developed for measuring corn (Zea mays) kernel mechanical damage and mold damage. Mechanical damage was determined using both single-kernel and batch analysis by extracting from kernel images the damaged area ...
H.F. Ng; W.F. Wilcke; R.V. Morey; J.P. Lang
core
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source