Results 141 to 150 of about 665,980 (290)

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

open access: yesMolecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed   +8 more
wiley   +1 more source

MECHANICAL & ELECTRICAL ENGINEERING TECHNOLOGY

open access: yesJixie chuandong, 2015
<正>《机电工程技术》杂志创刊于1971年,为国际大16开本(210mm×285mm),全彩+黑白印刷,月刊(每月20日出版),国内外公开发行,在制造业影响大、读者面广,由广东省机械研究所、广东省机械技术情报站和广东省机械工程学会联合主办。本刊是经过国家科技部、国家新闻出版总署批准出版的大型综合性机电期刊,专注报道机电工业领域的行业动态、先进技术、市场趋势及供求信息,面向机电产品企业高级管理人员、生产设计部门技术人员、产品和市场部经理,
doaj  

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

open access: yesMolecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho   +11 more
wiley   +1 more source

PRODUCT AESTHETICS FOR MECHANICAL ENGINEERS

open access: yesJournal of Industrial Design and Engineering Graphics, 2019
This paper gives a scope of course called Product aesthetics at Mechanical faculty, University in Belgrade, Serbia. During this course students are learning about standards and laws in process of product design. With this knowledge students are able to create more profound ability of aesthetic evaluation and form aesthetic judgement of in creating ...
Stojićević, Miša   +4 more
openaire   +4 more sources

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

open access: yesMolecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp   +13 more
wiley   +1 more source

Dynamic behavior of double and triple adjacent 2D hills using boundary element method

open access: yesHeliyon, 2019
A 2D boundary element method with material damping is developed in order to seismic investigation of constructions with different configurations.
Mobin Afzalirad   +2 more
doaj  

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