Results 151 to 160 of about 727,529 (282)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Mechanical Engineering

, 2017
  +6 more sources

MechRAG: a multimodal large language model for mechanical engineering. [PDF]

Commun Eng
Li S, Corney J.
europepmc   +1 more source

INVESTIGATING THE EFFECT OF THEORETICAL AND LABORATORY TEACHING ON THE STUDENTS’ ACADEMIC PERFORMANCE IN MECHANICAL ENGINEERING

, 2015
Sandeep Chowdhry
openalex   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

MECHANICAL & ELECTRICAL ENGINEERING TECHNOLOGY

Jixie chuandong, 2016
<正>创刊于1971年（月刊）《机电工程技术》杂志创刊于1971年,为国际大16开本（210mm×285mm）,全彩+黑白印刷,月刊（每月20日出版）,国内外公开发行,在制造业影响大、读者面广,由广东省机械研究所、广东省机械技术情报站和广东省机械工程学会联合主办。本刊是经过国家科技部、国家新闻出版总署批准出版的大型综合性机电期刊,专注报道机电工业领域的行业动态、先进技术、市场趋势及供求信息 ...
doaj  

Research on the maker learning experiences of engineering college students majoring in mechanical engineering in China. [PDF]

Sci Rep
Yang W, Chen P.
europepmc   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Bio-inspired designs: leveraging biological brilliance in mechanical engineering-an overview. [PDF]

3 Biotech
Fattepur G, Patil AY, Kumar P, Kumar A, Hegde C, Siddhalingeshwar IG, Kumar R, Khan TMY.   +7 more
europepmc   +1 more source