Results 41 to 50 of about 665,980 (290)

The intracellular domain of TLR2 is capable of high‐affinity Zn binding: possible outcomes for the receptor activation

FEBS Letters, EarlyView.
Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa, Cong Lin, Irina A. Talyzina, Marina V. Goncharuk, Eduard V. Bocharov, Alexander S. Arseniev, Xiaohui Wang, Sergey A. Goncharuk, Konstantin S. Mineev   +8 more
wiley   +1 more source

Engineering Mechanics

This book serves as a detailed guide to the principles of mechanics, offering in-depth coverage of both statics and dynamics. It is structured into five core chapters, each addressing different aspects of mechanical engineering and physics. The first chapter, Statics of Particles, introduces the fundamental concepts needed to analyze the forces acting
Mr.R.Prem Kumar, Dr. G. Ramesh, Mr. P. Karthick, Dr. M. Rajesh, Mr. R. Ramesh Babu   +4 more
openaire   +3 more sources

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Research and Development of the High Parameters of Gearbox in Level 4 Centripetal Turbine Power Generation System

Jixie chuandong, 2015
The design,manufacturing and the research and development of high parameter gearbox for generating electricity by utilizing the abandoned residual heat and pressure,residual gas resources of industrial production.
Yuan Yongchao, Tao Ye, Chen Yuan, Cao Yanjun, Yu Li, Zhengzhou Research Institute of Mechanical Engineering   +5 more
doaj  

60 years of education of women engineers in Vojvodina [PDF]

Tehnika, 2020
This paper aims to analyze the participation of the female population in mechanical engineering, to study the motives for their commitment to these studies, their status with respect to the majority male population, and the fulfillment of expectations by
Cvetićanin Livija J.
doaj  

Mobile Learning for Mechanical Engineers [PDF]

Society and Economy, 2006
The paper presents the first stage of a pilot project, which aims to introduce mobile learning (m-learning) in mechanical engineering education. Educational concepts and technological considerations are discussed first, together with basic assumptions and fundamental decisions related to the applied educational approach and technology, including ...
Gyorgy Lipovszki, Istvan Molnar
openaire   +3 more sources

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source