Results 51 to 60 of about 7,260,892 (293)
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
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Summary of Research 2001, Department of Mechanical Engineering [PDF]
, 2001 The view expressed in this report are those of the authors and do not reflect the official policy or position of the Department of Defense or U.S. Government.This report contains project summaries ofthe research projects in the Department ofMechanical ...
Faculty of the Department of Mechanical Engineering, Naval Postgraduate School
core +2 more sources
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
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High-temperature quality of accelerated spheroidization on SUP9 leaf spring to enhance machinability
Heliyon, 2018 The high temperature on the austenitization showed the varied results in the fast spheroidization in high carbon leaf spring steel SUP9/55CrMnA. The heating temperature was held for 15 minutes in the austenitization temperature at 800, 850, and 900 °C ...
Hendri Chandra +2 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
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Revisiting classical design in engineering from a perspective of frugality
Heliyon, 2017 The conservative nature of design in engineering has typically unleashed products fabricated with generous amounts of raw materials. This is epitomized by the factor of safety whose values higher than unity suggests various uncertainties of design that ...
Balkrishna C. Rao
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FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
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Lubricant flow analysis for effective lubrication of tractor forward/reverse clutch
Heliyon, 2017 Owing to the high power requirements of tractors, their low-power transmission gears often experience durability problems such as burning of the clutch.
Daekyung Noh +3 more
doaj +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
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