Results 71 to 80 of about 1,128,815 (309)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Model-based (Mechanical) Product Design [PDF]
, 2011 Lien vers la version éditeur: http://link.springer.com/chapter/10.1007/978-3-642-24485-8_40Mechanical product engineering is a research and industrial activity which studies the design of complex mechanical systems.
Lionel Roucoules +5 more
core +1 more source
Understanding the wire electrical discharge machining of Ti6Al4V alloy
Heliyon, 2019 Non-conventional machining process for instance, wire electrical discharge machining (WEDM) of titanium alloys is gaining attention due to non-contact nature of this process.
A. Pramanik, A.K. Basak, C. Prakash
doaj +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
A novel type of semi-active jet turbulence grid
Heliyon, 2018 This article describes a novel approach to generate increased turbulence levels in an incoming flow. It relies on a cost-effective and robust semi-active jet grid, equipped with flexible tubes as moving elements attached onto tube connections placed at ...
N. Szaszák +5 more
doaj +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Jurnal Pendidikan Teknologi dan Kejuruan, 2019 Vocational education building and development must consider the needs of the industry and the demands of 21st-century skills graduates. For these two requirements, it is necessary to innovate the learning model to improve the students’ learning ...
Heri Yudiono +2 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Collaborative Reverse Engineering Design Experiment Using PLM Solutions [PDF]
, 2011 The current climate of economic competition forces businesses to adapt to the expectations of their customers. To achieve this, in spite of the increasing complexity of mechanical systems, it becomes necessary, amongst other things, to reduce design time.
AOUSSAT, Améziane +3 more
core
Heliyon, 2019 In the present investigation raw oil (jatropha, soybean, and waste cooking fuel) has analyzed to prove its suitability as an alternative fuel in compression ignition (CI) engines.
Prem Kumar Chaurasiya +3 more
doaj +1 more source