Results 81 to 90 of about 1,128,815 (309)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Bond graph analysis in robust engineering design [PDF]

, 2000
Within engineering design, optimization often involves building models of working systems to improve design objectives such as performance, reliability and cost.
GABBRIELLI R., de Mast, J., Does, R.J.M.M., BRAGLIA, MARCELLO, van den Heuvel, E.R., BRAGLIA M., Heuvel, van den, E.R., Bates, RA, YANG, Zhenlin, BEVILACQUA M., Atherton, MA, GABBRIELLI, ROBERTO, Bates, R. A., Yang, Z., Schippers, W.A.J., Atherton, M. A., Mast, de, J., Does, R.J.M.M.; id_orcid, BEVILACQUA, MAURIZIO, Wu, Shuo-jye; Tsai, Tzong-ru, Xie, M., Gaudoin, O., Wu, Shuo-jye   +22 more
core   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Finite Element Analysis of an Electro-Mechanical Knee Loading Device

, 2016
The mechanical loading of knee is an effective regimen for treatment of bone related ailments like fractures, osteoarthritis, and osteoporosis [1–2]. Efficacy of knee loading is evident from the previous studies done on rodents and other small animals [3]
Sai Krishna Prabhala, Chien, Stanley, Yokota, Hiroki, Hiroki Yokota, Sohel Anwar, Stanley Chien, Prabhala, Sai Krishna, Anwar, Sohel   +7 more
core   +1 more source

60 years of education of women engineers in Vojvodina [PDF]

Tehnika, 2020
This paper aims to analyze the participation of the female population in mechanical engineering, to study the motives for their commitment to these studies, their status with respect to the majority male population, and the fulfillment of expectations by
Cvetićanin Livija J.
doaj  

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Introduction to Mechanical Engineering

, 2012
This course will introduce the student to the field of mechanical engineering and the interplay of physics, mathematics, communications, and sciences necessary for the study, design, and manufacture of mechanical products and systems.
The Saylor Foundation
core  

Engineering State of Mind Instrument: A tool for Self-Assessment

, 2020
Students in their first and second year in an engineering major often experience an internal struggle. They wonder if they are meant to be an engineer and if they will be successful in their program, even if they are in good academic standing.
Gurganus, Jamie Rebecca
core   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source