Results 51 to 60 of about 2,446,527 (268)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Problem-based learning in facilities planning: a pilot implementation [PDF]
, 2005 In Universiti Teknologi Malaysia, Problem Based Learning (PBL) is proposed as an alternative to lectures in moulding engineering graduates to acquire attributes that are required to excel in today’s k-economy.
Abd. Hamid, Mohd. Kamaruddin +3 more
core
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Engineering design project : series 1 [PDF]
, 2017 This book is a compilation of engineering design projects which illustrates a detail explanation on the design process including all tools and methods involved in each design stage.
core
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Mechanical dissection in an introductory engineering design module [PDF]
, 2010 The introductory design module for first year students in the Department of Mechanical Engineering at the University of Strathclyde uses mechanical dissection as a focus for learning activities that seek to integrate engineering science with the prior ...
Jenkins, Peter, McLaren, A.J.
core
An Introduction to Multiscale Modeling with Applications [PDF]
, 2013 This book collects the slides prepared for the course of Advanced Engineering Thermodynamics (Master of Science in Mechanical Engineering) and those for the course of Multiscale Modelling and Simulation of Molecular and Mesoscopic Dynamics (PhD Program ...
P. Asinari, E. Chiavazzo
core +1 more source
60 years of education of women engineers in Vojvodina [PDF]
Tehnika, 2020 This paper aims to analyze the participation of the female population in mechanical engineering, to study the motives for their commitment to these studies, their status with respect to the majority male population, and the fulfillment of expectations by
Cvetićanin Livija J.
doaj
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Mechanics of Hip Dysplasia Reduction in Infants Using the Pavlik Harness: A Physics Based Computational Model [PDF]
, 2013 Biomechanical factors influencing the reduction of dislocated hips with the Pavlik harness in patients of Developmental Dysplasia of the Hip (DDH) were studied using a three-dimensional computer model simulating hip reduction dynamics in (1) subluxated ...
Ardila, Orlando +5 more
core +1 more source