Results 51 to 60 of about 4,588 (269)
BioengineeringMedical device-related infections (DRIs), especially prevalent among critically ill patients, impose significant health and economic burdens and are mainly caused by bacteria.
Joana P. Martins +3 more
doaj +1 more source
The homodimeric ATP‐binding cassette transporter LmrA mediates multidrug transport by an alternating two‐site (two‐cylinder engine) mechanism [PDF]
The EMBO Journal, 2000 The bacterial LmrA protein and the mammalian multidrug resistance P-glycoprotein are closely related ATP-binding cassette (ABC) transporters that confer multidrug resistance on cells by mediating the extrusion of drugs at the expense of ATP hydrolysis.
van Veen, HW +4 more
openaire +3 more sources
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Influence of DMSO Non-Toxic Solvent on the Mechanical and Chemical Properties of a PVDF Thin Film
Applied SciencesPiezoelectric materials such as PVDF and its copolymers have been widely studied in different areas and with promising applications, such as haptic feedback actuators or deformation sensors for aided-mobility scenarios.
António Diogo André +2 more
doaj +1 more source
Scientific-Research Activity of the Department of Transport Machines, Faculty of Mechanical Engineering -Technical University of Liberec at The Field of the Vehicles Engines [PDF]
Communications - Scientific letters of the University of Zilina, 2001 The paper shows the technical solutions and the results of the research works, connected with the conversion of Diesel engines to spark ignition (SI) gas fuelled engines for the vehicles. The attention is paid to the comparision of the exhaust pollutions from the gas fuelled engines and from original diesel engines.
Stanislav Beroun +4 more
openaire +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Applied SciencesPelvic organ prolapse (POP) cases have been rising, affecting women’s quality of life. Severe cases often require surgical mesh implants, which can cause complications like tissue erosion and infection, leading the FDA to ban transvaginal meshes for POP.
Joana Pinheiro Martins +4 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
MacromolIn recent years, pelvic organ prolapse (POP) cases have been rising, affecting women’s quality of life. Synthetic surgical transvaginal meshes used for POP treatment were withdrawn from the United States market in 2019 due to high risks, including ...
Joana Pinheiro Martins +4 more
doaj +1 more source