Results 71 to 80 of about 4,588 (269)

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Harnessing prokaryotic amino acid transporters for metabolic engineering: mechanisms and biotechnological applications

Synthetic and Systems Biotechnology
As fundamental bioactive molecules and building blocks of cellular structures, amino acids play a crucial role in sustaining life, reflected in a global market valued at tens of billions of dollars. Recently, microbial fermentation has become a leading alternative to chemical synthesis and enzymatic catalysis for amino acid production, driving the need
Junyao Huang, Wenming Wu, Zhicheng Fu, Chunyu Chao, Chongde Lai, Xiaoyu Wu, Hui Yang, Xiaohe Chu, Bangce Ye, Bin Zhang   +9 more
openaire   +2 more sources

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

An Approach to Modeling and Developing Virtual Sensors Used in the Simulation of Autonomous Vehicles

Sensors
A virtual model enables the study of reality in a virtual environment using a theoretical model, which is a digital image of a real model. The complexity of the virtual model must correspond to the reality of the evaluated system, becoming as complex as ...
István Barabás, Calin Iclodean, Horia Beles, Csaba Antonya, Andreia Molea, Florin Bogdan Scurt   +5 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Manufacturing Companies Industry 4.0 maturity level: A multivariate analysis

Journal of Industrial Engineering and Management
Purpose: This research investigates Portuguese manufacturing companies' Industry 4.0 (I4.0) maturity perception level and proposes an index to measure that aim.
Luis Miguel Ciravegna Martins da Fonseca, Teresa Pereira, Marisa Oliveira, Fernanda Ferreira, Mihail Busu   +4 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

A review of intrinsic self-healing capability of engineered cementitious composites: Recovery of transport and mechanical properties

Construction and Building Materials, 2015
Abstract The need for viable materials in sustainable infrastructures is driving the creation of multifunctional strain-hardening cementitious composites that combine brittle cementitious matrices with fibers. Unlike conventional concrete, these materials typically show multiple microcracking behavior with strain-hardening response under tensile ...
Yildirim, Gurkan, Keskin, Ozlem Kasap, Keskin, Suleyman Bahadir, Sahmaran, Mustafa, Lachemi, Mohamed   +4 more
openaire   +3 more sources

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source