Results 71 to 80 of about 5,213 (312)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Numerical analysis of plasma gasification of hazardous waste using Aspen Plus

Energy Reports, 2023
The COVID-19 pandemic raised the problem of dealing with the hazardous wastes generated. The World Health Organization (OMS) recommends the treatment of these wastes at high temperatures in order to neutralize their negative impact.
Pedro Pitrez, Eliseu Monteiro, Abel Rouboa   +2 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Development of an aircraft design expert system [PDF]

, 1988
The aircraft design process is characterised by the application of a wide range of knowledge across many disciplines based upon a certain degree of judgement and experience of the designer. A two pass approach has been taken towards the development of
Alsina, J.
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Characterization of the anisotropic mechanical properties of excised human skin

, 2012
The mechanical properties of skin are important for a number of applications including surgery, dermatology, impact biomechanics and forensic science.
Karine Bruyère, Otténio, Mélanie, Aisling Ní Annaidh, Michel Destrade, Gilchrist, Michael D., Otténio, Mélaine, Ní Annaidh, Aisling, Destrade, Michel, Bruyère, Karine, Gilchrist, M. D., Michael D. Gilchrist, Mélanie Otténio, Gilchrist, Michael, D   +12 more
core   +1 more source

Three-Dimensional Melted Electrowriting Drug Coating Fibers for the Prevention of Device-Associated Infections: A Pilot Study

Bioengineering
Medical device-related infections (DRIs), especially prevalent among critically ill patients, impose significant health and economic burdens and are mainly caused by bacteria.
Joana P. Martins, Elisabete T. da Silva, António A. Fernandes, Sofia Costa de Oliveira   +3 more
doaj   +1 more source

Scientific-Research Activity of the Department of Transport Machines, Faculty of Mechanical Engineering -Technical University of Liberec at The Field of the Vehicles Engines [PDF]

Communications - Scientific letters of the University of Zilina, 2001
The paper shows the technical solutions and the results of the research works, connected with the conversion of Diesel engines to spark ignition (SI) gas fuelled engines for the vehicles. The attention is paid to the comparision of the exhaust pollutions from the gas fuelled engines and from original diesel engines.
Stanislav Beroun, Ladislav Bartonicek, Josef Laurin, Lubomir Moc, Celestyn Scholz   +4 more
openaire   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Development of novel flax bio-matrix composites for non-structural and structural vehicle applications [PDF]

, 2015
The use of natural fibres (e.g. flax, hemp etc.) instead of synthetic fibres (carbon and glass etc.) as composite reinforcements not only benefits the environment, but also provides economical lightweight products for transports.
Zhu, Jinchun
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