Results 81 to 90 of about 4,588 (269)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Calibration of the Intelligent Driver Model (IDM) at the Microscopic Level
Future TransportationThis paper presents a calibration technique for the Intelligent Driver Model (IDM), a car-following model that considers the physical interpretation of each parameter. Using an instrumented vehicle, trajectory data were gathered for a group of Portuguese
Luís Vasconcelos, Jorge M. Bandeira
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
International Journal of Financial StudiesIn the last 10 years, the global green bond market has reached an estimated value of USD 6.8 trillion. However, credibility concerns persist due to greenwashing risks and issues regarding the reporting system.
Venera-Stanca Nicolici +3 more
doaj +1 more source
Altering the Course of Technologies to Monitor Loosening States of Endoprosthetic Implants
Sensors, 2019 Musculoskeletal disorders are becoming an ever-growing societal burden and, as a result, millions of bone replacements surgeries are performed per year worldwide.
João Henrique Cachão +7 more
doaj +1 more source
UTILIZATION OF THE PARAMETRIC TRANSPORTATION PROBLEM IN MECHANICAL ENGINEERING [PDF]
The International Conference on Applied Mechanics and Mechanical Engineering, 1984 Said HASSAN, M. OSMAN, A. ABOUEL NOUR
openaire +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
A Column Generation Based Hyper-Heuristic to the Bus Driver Scheduling Problem
Discrete Dynamics in Nature and Society, 2015 Public transit providers are facing continuous pressure to improve service quality and reduce operating costs. Bus driver scheduling is among the most studied problems in this area.
Hong Li, Ying Wang, Shi Li, Sujian Li
doaj +1 more source