Results 51 to 60 of about 49,797 (243)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Modelo dinâmico de simulação e otimização da força normal de reação do solo para um mecanismo de corte basal Dynamic model of simulation and optimization of the normal force of soil reaction for a mechanism of base cutter

Engenharia Agrícola, 2005
O modelo físico foi baseado no método de Newton-Euler, sendo o mesmo desenvolvido utilizando o programa computacional científico Mathematica®. Realizaram-se várias simulações, nas quais se procurou obter a força normal de reação do solo variando ...
Carlos E. S. Volpato, Oscar A. Braunbeck, Carlos A. A. de Oliveira   +2 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Ultrastable and High-Performance Silk Energy Harvesting Textiles

Nano-Micro Letters, 2019
Energy harvesting textiles (EHTs) have attracted much attention in wearable electronics and the internet-of-things for real-time mechanical energy harvesting associated with human activities.
Chao Ye, Shaojun Dong, Jing Ren, Shengjie Ling   +3 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Research evaluation of mechanical cutting technology of mulberry branch

Journal of Hebei University of Science and Technology, 2016
China is the world's largest silkworm cocoon and raw silk producer and exporter. However, as the labor price increases quickly, the sericulture production costs increases, the comparative benefits of sericulture production decreases, and the farmers ...
Zhanhua SONG, Fade LI, Tianhao GAO, Yudao LI, Yinfa YAN   +4 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Suitability Of Plum And Prune Cultivars, Grown In A High Density Planting System, For Mechanical Harvesting With A Canopy Contact, Straddle Harvester

Journal of Horticultural Research, 2015
The relation of hand-harvesting cost in plum and prune production to the total costs amounts to 25-40%. Mechanical harvesting makes it possible to cut drastically both the harvesting and total costs.
Mika Augustyn, Buler Zbigniew, Rabcewicz Jacek, Białkowski Paweł, Konopacka Dorota   +4 more
doaj   +1 more source

Intensive plum orchard with summer training and pruning

Advances in Horticultural Science, 2013
An intensive plum orchard model was created for two types of fruit harvesting: by hand and with a self-propelled straddle harvester working in continuous motion.
A. Mika, Z. Buler
doaj   +1 more source