Results 81 to 90 of about 230,916 (283)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Ab-Initio Calculation of Molecular Aggregation Effects: a Coumarin-343 Case Study [PDF]

, 2013
We present time-dependent density functional theory (TDDFT) calculations for single and dimerized Coumarin-343 molecules in order to investigate the quantum mechanical effects of chromophore aggregation in extended systems designed to function as a new ...
Agranovich V., Agranovich V. M., Blankenship R. E., Cao J., Cheng Y.-C., Clark T., Collini E., Cossi M., Curutchet C., Davydov A. S., Didraga C., Didraga C., Ditchfield R., Donghyun Lee, Dreuw A., Endo M., Engel G. S., Fink R. F., Fink R. F., Frisch M. J., Gross E., Hariharan P., Hehre W. J., Howard I. A., Hsu C.-P., Ivanic J., K. Birgitta Whaley, Kasha M., Klug A., Knoester J., Kowalski K., Krishnan R., Krueger B. P., Liu W., Loren Greenman, Löwdin P.-O., Ma Y.-Z., Madjet M. E., Madjet M. E., Miller R. A., Mohan Sarovar, Muh F., Mulliken R. S., Muñoz Losa A., Nam Y. S., Novoderezhkin V. I., Pan F., Perdew J. P., Perdew J. P., Peverati R., Peverati R., Piecuch P., Runge E., Sarovar M., Sarovar M., Schmidt M. W., Scholes G. D., Scholes G. D., Scholes G. D., Scholes G. D., Scholes G. D., Scholes G. D., Scholes G. D., Shao Y., Sinnokrot M. O., Stephens P. J., Tawada Y., van Amerongen H., Witus L. S., Wloch M., Zhao H. M., Zhao Y.   +71 more
core   +2 more sources

Modelo dinâmico de simulação e otimização da força normal de reação do solo para um mecanismo de corte basal Dynamic model of simulation and optimization of the normal force of soil reaction for a mechanism of base cutter

Engenharia Agrícola, 2005
O modelo físico foi baseado no método de Newton-Euler, sendo o mesmo desenvolvido utilizando o programa computacional científico Mathematica®. Realizaram-se várias simulações, nas quais se procurou obter a força normal de reação do solo variando ...
Carlos E. S. Volpato, Oscar A. Braunbeck, Carlos A. A. de Oliveira   +2 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The Status of Labor-Saving Mechanization in Fruits and Vegetables [PDF]

The objective of this paper is to examine the status of labor-saving mechanization in U.S. fruit and vegetable harvesting. Fruit and vegetable harvest mechanization has several potential advantages: reduced harvest costs, eliminate problems associated ...
Wallace E. Huffman
core  

Relationship between seed harvesting method and seed physiological quality for a number of Pioneer maize hybrids [PDF]

, 2012
The seed germination and seed vigor of eight Pioneer Hi-Bred maize hybrids were evaluated immediately after harvesting and a year later. The aim was to determine whether the seed showed loss of germination and vigor when shelled mechanically.
Anda, Angéla, Berzy, Tamás, Ertsey, Katalin, Varga, Péter   +3 more
core   +1 more source

On energy harvesting from ambient vibration

, 2006
Future MEMS devices will harvest energy from their environment. One can envisage an autonomous condition monitoring vibration sensor being powered by that same vibration, and transmitting data over a wireless link; inaccesible or hostile environments are
Stephen, N.G.
core   +1 more source

Research evaluation of mechanical cutting technology of mulberry branch

Journal of Hebei University of Science and Technology, 2016
China is the world's largest silkworm cocoon and raw silk producer and exporter. However, as the labor price increases quickly, the sericulture production costs increases, the comparative benefits of sericulture production decreases, and the farmers ...
Zhanhua SONG, Fade LI, Tianhao GAO, Yudao LI, Yinfa YAN   +4 more
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source