Results 61 to 70 of about 110,588 (202)

Trilayered biomimetic hydrogel scaffolds with dual-differential microenvironment for articular osteochondral defect repair

Materials Today Bio
Commonly, articular osteochondral tissue exists significant differences in physiological architecture, mechanical function, and biological microenvironment.
Hongying Chen, Jinyi Huang, Xiaomeng Li, Weiwei Zhao, Yujie Hua, Zhenfeng Song, Xianwei Wang, Zhikun Guo, Guangdong Zhou, Wenjie Ren, Yongkun Sun   +10 more
doaj   +1 more source

Novel Nanomaterials Enable Biomimetic Models of the Tumor Microenvironment

Journal of Nanotechnology, 2017
In the complex tumor microenvironment, chemical and mechanical signals from tumor cells, stromal cells, and the surrounding extracellular matrix influence all aspects of disease progression and response to treatment.
Marshall Hunter Joyce, Shane Allen, Laura Suggs, Amy Brock   +3 more
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Natural medicines target tumor vascular microenvironment to inhibit tumor

Genes and Diseases
The abnormally active tumor vasculature provides a good blood supply for the rapid proliferation of tumors. The tumor microenvironment of tumor cells is associated with the secretion of a lot of angiogenic factors to promote the formation of blood ...
Yirui Lu, Zhiliang Guo, Hong Li, Jiao Wen, Xiaoyun Zhang, Xiumei Guan, Xiaodong Cui, Min Cheng   +7 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Feeling Stress: The Mechanics of Cancer Progression and Aggression

Frontiers in Cell and Developmental Biology, 2018
The tumor microenvironment is a dynamic landscape in which the physical and mechanical properties evolve dramatically throughout cancer progression. These changes are driven by enhanced tumor cell contractility and expansion of the growing tumor mass, as
Josette M. Northcott, Ivory S. Dean, Janna K. Mouw, Valerie M. Weaver, Valerie M. Weaver, Valerie M. Weaver, Valerie M. Weaver, Valerie M. Weaver   +7 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Mechanical cues enhance chondrocyte function: Insights from mechanoreception, regulation, and biological responses

Mechanobiology in Medicine
Chondrocytes, the sole cell type in articular cartilage, are responsible for synthesizing and maintaining the primary components of the extracellular matrix (ECM).
Gaige Wu, Shuai Chen, Qian Li, Min Zhang, Fuyang Cao, Junchao Wei, Li Guo, Pengcui Li, Xiaochun Wei, Quanyou Zhang   +9 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source