Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Nonlinearities investigation and experimental validation insights into mechanical model of yoke-type inerter for enhanced vibration suppression. [PDF]
Sci RepZhang R, Tao Q, Zhang L, Hao L, Xue S.
europepmc +1 more source
Predicting the Non-Deterministic Response of a Micro-Scale Mechanical Model Using Generative Adversarial Networks. [PDF]
Materials (Basel), 2022 Argilaga A, Zhuang D.
europepmc +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
A physico-mechanical model of postnatal craniofacial growth in human. [PDF]
iScienceLiang C +9 more
europepmc +1 more source
Three-dimensional opto-thermo-mechanical model for predicting photo-thermal optical coherence tomography responses in multilayer geometries. [PDF]
Biomed Opt Express, 2022 Salimi MH, Villiger M, Tabatabaei N.
europepmc +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
A quadriphasic mechanical model of the human dermis. [PDF]
Biomech Model MechanobiolSachs D +6 more
europepmc +1 more source
Study of the Interfacial Bond Behavior between CFRP Grid-PCM Reinforcing Layer and Concrete via a Simplified Mechanical Model. [PDF]
Materials (Basel), 2021 Dai H, Wang B, Zhang J, Zhang J, Uji K.
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Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source