Results 211 to 220 of about 27,702,308 (366)

Estimating ankle joint angle from skeletal geometry: a mechanical model of the calcaneal lever in terrestrial mammals. [PDF]

PeerJ
Mizuno F, Fujiwara SI.
europepmc   +1 more source

Thermally damaged porcine skin is not a surrogate mechanical model of human skin. [PDF]

Sci Rep, 2022
Gallagher S, Kruger U, Josyula K, Rahul, Gong A, Song A, Sweet R, Makled B, Parsey C, Norfleet J, De S.   +10 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

A dedicated animal model for mechanical thrombectomy in acute stroke

, 2006
BACKGROUND: Recent studies have focused on mechanical thrombectomy as a means to reduce the time required for revascularization and increase the revascularization rate in acute stroke.
Fleischmann, A, Schroth, G, Gralla, J, Fandino, J, Slotboom, J, Remonda, L, Brekenfeld, C   +6 more
core  

Evaluation of Polypropylene Reusability Using a Simple Mechanical Model Derived from Injection-Molded Products. [PDF]

Polymers (Basel)
Takayama T, Takahashi R, Konno N, Sato N.   +3 more
europepmc   +1 more source

A mechanical model of early somite segmentation. [PDF]

iScience, 2021
Adhyapok P, Piatkowska AM, Norman MJ, Clendenon SG, Stern CD, Glazier JA, Belmonte JM.   +6 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Mechanical Model of Tensile Loading of Geotechnical Reinforcement Materials. [PDF]

Materials (Basel)
Liu H, Zhang Z, Long Z, He B, Chen F, Chen Z, Lin Y.   +6 more
europepmc   +1 more source

Mechanical model of steady-state and inflammatory conditions in patients with relapsing polychondritis: A review. [PDF]

Medicine (Baltimore), 2022
Shimizu J, Suzuki N.
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source