Results 191 to 200 of about 29,278,787 (347)

Mechanical model of steady-state and inflammatory conditions in patients with relapsing polychondritis: A review. [PDF]

Medicine (Baltimore), 2022
Shimizu J, Suzuki N.
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Mechanical Model of Tensile Loading of Geotechnical Reinforcement Materials. [PDF]

Materials (Basel)
Liu H, Zhang Z, Long Z, He B, Chen F, Chen Z, Lin Y.   +6 more
europepmc   +1 more source

Improved thermal conductivity of polyurethane (PU)-/SiC composite fabricated via solution casting method and its mechanical model for prediction and comparison. [PDF]

Heliyon, 2023
Somdee P, Ansari MA, Szabo T, Marossy K.
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

A mechanical model for lateral and axial impacts and quantification of effect on viability of SHSY5Y neuroblastoma cells. [PDF]

Sci Rep
Akhtaruzzaman R, Awad K, Koster A, Varanasi V, Brotto M, Adnan A.   +5 more
europepmc   +1 more source

A coarse-grained mechanical model for folding and unfolding of tropoelastin with possible mutations. [PDF]

Acta Biomater, 2021
Florio G, Pugno NM, Buehler MJ, Puglisi G.   +3 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Quantifying fracture roughness effects on coal mine spontaneous combustion through a coupled thermos hydro mechanical model. [PDF]

Sci Rep
Lu G, Zhao G, Yu L, Zhang M, Wang X.
europepmc   +1 more source

Effects of Thermal Stress on the Formation and Cracking Behavior of Nickel-Based Superalloys by Selective Laser Melting Based on a Coupled Thermo-Mechanical Model. [PDF]

Materials (Basel), 2022
Nie S, Li L, Wang Q, Zhao R, Lin X, Liu F.   +5 more
europepmc   +1 more source