Results 121 to 130 of about 1,339,441 (314)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Thermal Evolution of Expanded Phases Formed by PIII Nitriding in Super Duplex Steel Investigated by In Situ Synchrotron Radiation

Metals
The Plasma Immersion Ion Implantation (PIII) nitriding was used to form a modified layer rich in expanded austenite (γN) and expanded ferrite (αN) phases in super duplex steel.
Bruna Corina Emanuely Schibicheski Kurelo, João Frederico Haas Leandro Monteiro, Gelson Biscaia de Souza, Francisco Carlos Serbena, Carlos Maurício Lepienski, Rodrigo Perito Cardoso, Silvio Francisco Brunatto   +6 more
doaj   +1 more source

Determination of wood strength properties through standard test procedures

, 2012
In this study a review of existing recognised standards for wood mechanical testing was conducted. This review considers tensile, compressive, bending and shear test methodologies from a range of sources.
Perera, Noel, Naylor, Andrew, Hackney, Philip   +2 more
core  

Effect of the over-ageing treatment on the mechanical properties of AA2024 aluminum alloy. [PDF]

, 2012
The evolution of the hardness of the over-ageing AA2024 alloy scale was followed by measurements of Vickers hardness. The nanoindentation is adapted to the determination of elastoplastic properties (hardness and Young’s modulus) of the matrix and also of
Alexis, Joël, Vulpe, Sanda, Radutoiu, Nicoleta, Abrudeanu, Marioara, Marioara Abrudeanu, Petit, Jacques-Alain, Lacroix, Loïc, Rizea, Vasile, Vasile Rizea, Nicoleta Radutoiu, Jacques-Alain Petit, Joël Alexis, Loic Lacroix, Sanda Vulpe   +13 more
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Topography and mechanical properties of single molecules of type I collagen using atomic force microscopy

, 2005
Although the mechanical behavior of tendon and bone has been studied for decades, there is still relatively little understanding of the molecular basis for their specific properties.
Bozec, L., Laurent Bozec, Horton, Michael, Horton, M., Michael Horton, Bozec, Laurent   +5 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Composite mechanical properties for use in structural analysis [PDF]

In order to be able to undertake an analysis of a component the designer will need to know the properties of the material being used. The aim of this work is help the design engineer such that the mechanical properties of continuous glass fibre ...
Pinfold, Martyn Keith
core  

Molecular dynamics predictions of thermal and mechanical properties of thermoset polymer EPON862/DETDA

, 2011
We use molecular dynamics (MD) to perform an extensive characterization of the thermo-mechanical response of a thermoset polymer composed of epoxy EPON862 and curing agent DETDA.
Strachan, Alejandro, Chunyu Li, Li, Chunyu, Alejandro Strachan   +3 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source