Results 131 to 140 of about 1,339,441 (314)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Computational Modeling of High-Speed Flow of Two-Phase Hydrogen through a Tube with Abrupt Expansion

Hydrogen
Hydrogen can become a prevalent renewable fuel in the future green economy, but technical and economic hurdles associated with handling hydrogen must be overcome.
Konstantin I. Matveev
doaj   +1 more source

Correlation between the mechanical and histological properties of liver tissue

, 2015
In order to gain further insight into the mechanisms of tissue damage during the progression of liver diseases as well as the liver preservation for transplantation, an improved understanding of the relation between the mechanical and histological ...
Başdoğan, Çağatay; Yarpuzlu, Berkay; Ayyıldız, Mehmet; Tok, Olgu Enis; Aktaş, Ranan Gülhan
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Investigation on Friction Stir Welding Parameters: Mechanical Properties, Correlations and Corrosion Behaviors of Aluminum/Titanium Dissimilar Welds

Crystals
In industrial applications, welding of dissimilar metals such as aluminum (Al) and titanium (Ti) is a prerequisite for the development of hybrid components with improved mechanical and corrosion properties. However, dissimilar welding of the Al/Ti system
Amlan Kar, Sribalaji Mathiyalagan, Sergey Malopheyev, Rustam Kaibyshev, Satyam Suwas, Satish V. Kailas   +5 more
doaj   +1 more source

The effect of alkalisation on the mechanical properties of natural fibres

, 2008
A study on the effect of alkalisaton using 3% NaOH solution was carried out on Flax, Kenaf, Abaca and Sisal to observe the impact that the common pre-treatment process has on fibre mechanical properties.
Symington, Mark C., David-West, Opukuro S., Pethrick, Richard A., Banks, William M., Thomason, J.L.   +4 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Solidification behaviour and mechanical properties of cast Mg-alloys and Al-based particulate metal matrix composites under intensive shearing

, 2011
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Magnesium alloys, as the lightest of all structural metallic materials, and aluminium-based particulate metal matrix composites (PMMCs), offering unified ...
Tzamtzis, Spyridon
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source