Results 91 to 100 of about 38,969 (262)
Case Studies in Construction MaterialsRecent advances highlight the potential of low-carbon concrete using recycled aggregates from precast rejects. This material, called precast recycled aggregate concrete (PRAC), shows superior properties compared to traditional recycled aggregate concrete.
Yong Yu +4 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
FEBS Letters, EarlyView.Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley +1 more source
Case Studies in Construction MaterialsA key and urgent scientific issue is how to characterize the complex intergranular contact state and mechanical behavior evolution of sand–fines mixed materials and then show how this state contributes to the static and dynamic properties of such ...
Tianzhu Hang +5 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Results in EngineeringQuantifying high-temperature mechanical degradation in metals is essential for designing components in aerospace, automotive, and power generation applications.
Amany Khaled Sayed +2 more
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Mechanical properties of new type of joint waterstop for high CFRDs and its application
Yantu gongcheng xuebaoThe concrete face rockfill dam (CFRD) is one of the most competitively powerful dam types now. In order to ensure the safety of high CFRDs the stress and strain behaviors of dam body and concrete face as well as the displacements of joints have become ...
LI Nenghui1 , WANG Li'an1, REN Qiang1, ZHANG Zhitao1, ZHANG Xian1, WANG Xinqi2, DAI Qiaozhi2
doaj +1 more source
Modelling of a bridge stay cable for individual strand tensioning
Građevinar, 2014 Analytical expressions for determining the required tensioning force in strands, and the corresponding deformation of cables during the multi-cycle tensioning process, are derived in the paper based on the proposed mathematical model of a bridge stay ...
Marija Spasojević-Šurdilović +2 more
doaj +1 more source