Results 81 to 90 of about 5,284,833 (331)

Connecting caddisworm silk structure and mechanical properties: combined infrared spectroscopy and mechanical analysis [PDF]

Open Biology, 2016
The underwater silk of an aquatic casemaking caddisfly larvae (Hesperophylax occidentalis) is viscoelastic, and displays distinct yield behaviour, large strain cycle hysteresis and near complete recovery of its initial strength and stiffness when ...
Nicholas N. Ashton, Huaizhong Pan, Russell J. Stewart   +2 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Enhanced exfoliation technique for the separation of graphene nanosheets [PDF]

, 2010
Graphene sheets are carbon-based materials which combine exceptional electron conductivity, mechanical strength and optical transparency. Graphene nanosheets were fabricated by an enhanced, safer and mild technique in a shortened processing time. Samples
Dinc, Fatma, Dinç, Fatma, Okyay, Firuze, Saner, Burcu, Yurum, Yuda, Yürüm, Yuda   +5 more
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Observation of force-detected nuclear magnetic resonance in a homogeneous field [PDF]

, 2004
We report the experimental realization of BOOMERANG (better observation of magnetization, enhanced resolution, and no gradient), a sensitive and general method of magnetic resonance.
Leskowitz, G. M., Madsen, L. A., Weitekamp, D. P.   +2 more
core   +1 more source

Extreme mechanical diversity of human telomeric DNA revealed by fluorescence-force spectroscopy

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance G-quadruplex (GQ)–forming G4 DNA, made of four repeats of guanines, is implicated in many important processes. Telomeric GQs are being studied extensively as anticancer drug targets.
Jaba Mitra, Monika A. Makurath, Thuy T. M. Ngo, A. Troitskaia, Y. Chemla, T. Ha   +5 more
semanticscholar   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Mechanical Spectroscopy Of Ordered Binary Au-Cu

Archives of Metallurgy and Materials, 2015
We have studied a binary Au-Cu single crystal by mechanical spectroscopy. Upon very slow cooling from high temperatures, additional relaxation peaks arise at lower frequencies in isothermal spectra after the disappearing of the Zener peak below 665 K due
Tkalcec I., Mari D., Schaller R.
doaj   +1 more source

Production and mechanical characterization of graphene micro-ribbons

, 2019
Patterning of graphene into micro- and nano-ribbons allows for the tunability in emerging fields such as flexible electronic and optoelectronic devices, and is gaining interest for the production of more efficient reinforcement for composite materials ...
Carbone, Maria Giovanna Pastore, Galiotis, Costas, Makarona, Eleni, Manikas, Anastasios C., Tsamis, Christos, Tsoukleri, Georgia   +5 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source