Results 91 to 100 of about 1,892,709 (308)

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Quasi-static and dynamic experimental studies on the tensile strength and failure pattern of concrete and mortar discs

Scientific Reports, 2017
As concrete and mortar materials widely used in structural engineering may suffer dynamic loadings, studies on their mechanical properties under different strain rates are of great importance.
Xiaochao Jin, Cheng Hou, Xueling Fan, Chunsheng Lu, Huawei Yang, Xuefeng Shu, Zhihua Wang   +6 more
doaj   +1 more source

Vacuum mixing technology to improve the mechanical properties of ultra-high performance concrete [PDF]

, 2015
Ultra-high performance concrete is an important evolution in concrete technology, enabled by the combination of a good particle packing density, a suitable mixing procedure and compatible binders and admixtures.
De Schutter, Geert, Dils, Jeroen
core   +2 more sources

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Origin and tuning of bandgap in chiral phononic crystals

Communications Physics
The wave equation revealing the wave propagation in chiral phononic crystals, established through force equilibrium law, conceals the underlying physical information, such as the essence of the motion coupling and the inertial amplification effect.
Wei Ding, Rui Zhang, Tianning Chen, Shuai Qu, Dewen Yu, Liwei Dong, Jian Zhu, Yaowen Yang, Badreddine Assouar   +8 more
doaj   +1 more source

Experimental Investigation and Safety Classification Evaluation of Small Drone Collision with Humans

Biomimetics
The safety of small drones in collision with humans has become a key focus in engineering and research fields. This study presents a vertical drop test platform for collision tests involving three representative drones (Air, Mavic 2, and M200) impacting ...
Chunyu Bai, Yazhou Guo, Qinghua Qin, Yunlai Zhou, Zhigang Li, Yafeng Wang   +5 more
doaj   +1 more source

Determination of the Strain-Free Configuration of Multispan Cable

Shock and Vibration, 2015
For building a reasonable finite element geometric model, a method is proposed to determine the strain-free configuration of the multispan cable. The geometric conditions (the end conditions and the unstretched length conditions) as constraints for the ...
Chuancai Zhang, Qiang Guo, Xinhua Zhang
doaj   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source