Results 71 to 80 of about 4,274,589 (298)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Measurement Research of Motorized Spindle Dynamic Stiffness under High Speed Rotating

open access: yesShock and Vibration, 2015
High speed motorized spindle has become a key functional unit of high speed machine tools and effectively promotes the development of machine tool technology.
Xiaopeng Wang, Yuzhu Guo, Tianning Chen
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

A Novel Aerodynamic Force and Flutter of the High-Aspect-Ratio Cantilever Plate in Subsonic Flow

open access: yesShock and Vibration, 2020
This paper focuses on the derivation of the aerodynamic force for the cantilever plate in subsonic flow. For the first time, a new analytical expression of the quasi-steady aerodynamic force related to the velocity and the deformation for the high-aspect-
Li Ma   +5 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Approximate Analytical Methodology for the Restricted Three-Body and Four-Body Models Based on Polynomial Series

open access: yesInternational Journal of Aerospace Engineering, 2016
The restricted three-body problem (R3BP) and restricted four-body problem (R4BP) are modeled based on the rotating frame. The conservative autonomous system for the R3BP and nonautonomous system with period parametric resonance due to the fourth body are
Ying-Jing Qian   +3 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Mechanical Performance of Industrial Hemp Fibre Reinforced Polylactide and Unsaturated Polyester Composites [PDF]

open access: yes, 2010
This study investigated the effect of fibre content, fibre treatment and fibre/matrix interfacial strength on the mechanical properties of industrial hemp fibre reinforced polylactide (PLA) and unsaturated polyester (UPE) composites.
Sawpan, Moyeenuddin Ahmad
core  

Quasi-static and dynamic experimental studies on the tensile strength and failure pattern of concrete and mortar discs

open access: yesScientific Reports, 2017
As concrete and mortar materials widely used in structural engineering may suffer dynamic loadings, studies on their mechanical properties under different strain rates are of great importance.
Xiaochao Jin   +6 more
doaj   +1 more source

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