Results 51 to 60 of about 483,612 (267)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Journal of Materials Science: Materials in EngineeringAlthough metallic glasses (MGs) possess relatively low thermal expansion coefficient (α) compared to their crystalline counterparts due to the existence of free volume, their α-values are still too large to meet the demands of practical application. Here,
Yunhao Zhang +4 more
doaj +1 more source
International Journal of Polymer Science, 2015 The microstructures were fabricated by hot embossing method using biodegradable material PLGA poly(lactic-co-glycolic acid), to serve as the drug carriers in the drug delivery system.
Xiaopeng Wang, Wei Li, Tianning Chen
doaj +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Measurement Research of Motorized Spindle Dynamic Stiffness under High Speed Rotating
Shock and Vibration, 2015 High speed motorized spindle has become a key functional unit of high speed machine tools and effectively promotes the development of machine tool technology.
Xiaopeng Wang, Yuzhu Guo, Tianning Chen
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Mechanism of Mechanical Strengths for Corrugated Fiberboard.
JAPAN TAPPI JOURNAL, 1994 Mechanism of mechanical strengths is discussed for corrugated fiberboards of single face, single wall and double wall. The strength under the tensile load is discussed by the experimental results of the tensile deformation. Their strengths under the surface compression and the uniform bending made from the applied moment of the axis along the machine ...
openaire +2 more sources
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
A Novel Aerodynamic Force and Flutter of the High-Aspect-Ratio Cantilever Plate in Subsonic Flow
Shock and Vibration, 2020 This paper focuses on the derivation of the aerodynamic force for the cantilever plate in subsonic flow. For the first time, a new analytical expression of the quasi-steady aerodynamic force related to the velocity and the deformation for the high-aspect-
Li Ma +5 more
doaj +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source