Results 41 to 50 of about 483,612 (267)

Characteristics of Duplex Angular Contact Ball Bearing with Combined External Loads and Angular Misalignment

open access: yesApplied Sciences, 2020
As a kind of common phenomenon in practical engineering, misalignment error considerably changes the working performance of bearing. However, it has rarely attracted attention in the study of duplex angular contact ball bearings (DACBBs). To evaluate the
Tengfei Xu, Lihua Yang, Kai Wang
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Sieving Performance of Dual-Track Shale Shaker Based on DEM-MBD Coupling

open access: yesShiyou jixie
To improve the processing capacity of the shale shaker, meet the needs of different working conditions in the drilling process, and solve the problems of “screen blinding” and “mud runaway” occurring in the existing shale shaker, a “linear + variable ...
Lü Zhipeng   +4 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Vision-Based Damage Detection Method Using Multi-Scale Local Information Entropy and Data Fusion

open access: yesApplied Sciences
Low-spatial-resolution measurements from contact sensors and excessive measurement noise have impeded the implementation of vibration-based damage detection.
Yiming Zhang, Zili Xu, Guang Li, Cun Xin
doaj   +1 more source

The mechanical strength of maxillary complete dentures

open access: yesJournal of Biomedical Materials Research, 1984
AbstractA complete study of the static and dynamic strength of complete maxillary dentures was undertaken. First, the denture base material was investigated in its various forms from the point of view of tension, creep, relaxation, fatigue, and the effect of a corrosive environment.
Vlissidis, D., Paipetis, S.A.
openaire   +3 more sources

Damage Mechanisms and Mechanical Properties of High-Strength Multiphase Steels [PDF]

open access: yesMaterials, 2018
The usage of high-strength steels for structural components and reinforcement parts is inevitable for modern car-body manufacture in reaching lightweight design as well as increasing passive safety. Depending on their microstructure these steels show differing damage mechanisms and various mechanical properties which cannot be classified ...
Sebastian Heibel   +4 more
openaire   +3 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Ultra-broadband acoustic absorption with inhomogeneous high-order Fabry–Pérot resonances

open access: yesAPL Materials, 2023
We present an ultra-broadband acoustic metamaterial with inhomogeneous high-order Fabry–Pérot (FP) resonances that achieves near-perfect continuous absorption in the range of 400–10000 Hz.
Chongrui Liu   +4 more
doaj   +1 more source

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