Results 61 to 70 of about 5,040,527 (296)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
The influence of curing conditions on mechanical strength and porosity of geopolymers
, 2013 Geopolymers have been suggested to be used as construction, waste treatment and even drug delivery material due to its excellent mechanical strength, acid resistance and biocompatibility.
Mellgren, Torbjörn +3 more
core +2 more sources
Sieving Performance of Dual-Track Shale Shaker Based on DEM-MBD Coupling
Shiyou jixieTo improve the processing capacity of the shale shaker， meet the needs of different working conditions in the drilling process， and solve the problems of “screen blinding” and “mud runaway” occurring in the existing shale shaker， a “linear + variable ...
Lü Zhipeng +4 more
doaj +1 more source
Applied Sciences, 2020 As a kind of common phenomenon in practical engineering, misalignment error considerably changes the working performance of bearing. However, it has rarely attracted attention in the study of duplex angular contact ball bearings (DACBBs). To evaluate the
Tengfei Xu, Lihua Yang, Kai Wang
doaj +1 more source
Characterization of dentine to assess bond strength of dental composites [PDF]
, 2015 This study was performed to develop alternating dentine adhesion models that could help in the evaluation of a self-bonding dental composite. For this purpose dentine from human and ivory was characterized chemically and microscopically before and after ...
Bozec, L +13 more
core +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Vision-Based Damage Detection Method Using Multi-Scale Local Information Entropy and Data Fusion
Applied SciencesLow-spatial-resolution measurements from contact sensors and excessive measurement noise have impeded the implementation of vibration-based damage detection.
Yiming Zhang, Zili Xu, Guang Li, Cun Xin
doaj +1 more source
Ultra-broadband acoustic absorption with inhomogeneous high-order Fabry–Pérot resonances
APL Materials, 2023 We present an ultra-broadband acoustic metamaterial with inhomogeneous high-order Fabry–Pérot (FP) resonances that achieves near-perfect continuous absorption in the range of 400–10000 Hz.
Chongrui Liu +4 more
doaj +1 more source
Determination of wood strength properties through standard test procedures [PDF]
, 2012 In this study a review of existing recognised standards for wood mechanical testing was conducted. This review considers tensile, compressive, bending and shear test methodologies from a range of sources.
Perera, Noel +2 more
core