Results 61 to 70 of about 483,612 (267)

Approximate Analytical Methodology for the Restricted Three-Body and Four-Body Models Based on Polynomial Series

International Journal of Aerospace Engineering, 2016
The restricted three-body problem (R3BP) and restricted four-body problem (R4BP) are modeled based on the rotating frame. The conservative autonomous system for the R3BP and nonautonomous system with period parametric resonance due to the fourth body are
Ying-Jing Qian, Xiao-Dong Yang, Lei-Yu Yang, Wei Zhang   +3 more
doaj   +1 more source

The mechanical strength of film-coated tablets

Journal of Pharmacy and Pharmacology, 1979
AbstractThe mechanical strength of film-coated tablets has been assessed using the diametral compression test. The results show that the influence of the film is more complex than that suggested by Stern (1976). The film may increase the breaking load of the core itself by acting as a padding material during the test and also by filling in surface ...
J T, Fell, R C, Rowe, J M, Newton
openaire   +2 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Quasi-static and dynamic experimental studies on the tensile strength and failure pattern of concrete and mortar discs

Scientific Reports, 2017
As concrete and mortar materials widely used in structural engineering may suffer dynamic loadings, studies on their mechanical properties under different strain rates are of great importance.
Xiaochao Jin, Cheng Hou, Xueling Fan, Chunsheng Lu, Huawei Yang, Xuefeng Shu, Zhihua Wang   +6 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Origin and tuning of bandgap in chiral phononic crystals

Communications Physics
The wave equation revealing the wave propagation in chiral phononic crystals, established through force equilibrium law, conceals the underlying physical information, such as the essence of the motion coupling and the inertial amplification effect.
Wei Ding, Rui Zhang, Tianning Chen, Shuai Qu, Dewen Yu, Liwei Dong, Jian Zhu, Yaowen Yang, Badreddine Assouar   +8 more
doaj   +1 more source

Experimental Investigation and Safety Classification Evaluation of Small Drone Collision with Humans

Biomimetics
The safety of small drones in collision with humans has become a key focus in engineering and research fields. This study presents a vertical drop test platform for collision tests involving three representative drones (Air, Mavic 2, and M200) impacting ...
Chunyu Bai, Yazhou Guo, Qinghua Qin, Yunlai Zhou, Zhigang Li, Yafeng Wang   +5 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source